node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2cd6 | Trim69 | ENSMUSP00000094845 | ENSMUSP00000047627 | C2 calcium-dependent domain-containing 6. | E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis; Belongs to the TRIM/RBCC family. | 0.410 |
E4f1 | Trim69 | ENSMUSP00000062344 | ENSMUSP00000047627 | Transcription factor E4F1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription. | E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis; Belongs to the TRIM/RBCC family. | 0.427 |
Fam209 | Spaca9 | ENSMUSP00000029007 | ENSMUSP00000121846 | Family with sequence similarity 209. | Sperm acrosome-associated protein 9. | 0.728 |
Fam209 | Trim69 | ENSMUSP00000029007 | ENSMUSP00000047627 | Family with sequence similarity 209. | E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis; Belongs to the TRIM/RBCC family. | 0.563 |
Spaca9 | Fam209 | ENSMUSP00000121846 | ENSMUSP00000029007 | Sperm acrosome-associated protein 9. | Family with sequence similarity 209. | 0.728 |
Spaca9 | Trim69 | ENSMUSP00000121846 | ENSMUSP00000047627 | Sperm acrosome-associated protein 9. | E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis; Belongs to the TRIM/RBCC family. | 0.546 |
Trat1 | Trim15 | ENSMUSP00000155986 | ENSMUSP00000133953 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | Tripartite motif-containing 15. | 0.606 |
Trat1 | Trim23 | ENSMUSP00000155986 | ENSMUSP00000069371 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. | 0.650 |
Trat1 | Trim32 | ENSMUSP00000155986 | ENSMUSP00000062277 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | E3 ubiquitin-protein ligase TRIM32; Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin). May ubiquitinate BBS2 (By similarity). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha. | 0.710 |
Trat1 | Trim56 | ENSMUSP00000155986 | ENSMUSP00000058109 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | E3 ubiquitin-protein ligase TRIM56; E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity. In response to pathogen- and host-derived double- stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta. Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RAN [...] | 0.692 |
Trat1 | Trim69 | ENSMUSP00000155986 | ENSMUSP00000047627 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis; Belongs to the TRIM/RBCC family. | 0.519 |
Trim15 | Trat1 | ENSMUSP00000133953 | ENSMUSP00000155986 | Tripartite motif-containing 15. | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | 0.606 |
Trim15 | Trim23 | ENSMUSP00000133953 | ENSMUSP00000069371 | Tripartite motif-containing 15. | E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. | 0.440 |
Trim15 | Trim42 | ENSMUSP00000133953 | ENSMUSP00000035026 | Tripartite motif-containing 15. | Tripartite motif-containing protein 42; Belongs to the TRIM/RBCC family. | 0.475 |
Trim15 | Trim69 | ENSMUSP00000133953 | ENSMUSP00000047627 | Tripartite motif-containing 15. | E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis; Belongs to the TRIM/RBCC family. | 0.467 |
Trim23 | Trat1 | ENSMUSP00000069371 | ENSMUSP00000155986 | E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. | 0.650 |
Trim23 | Trim15 | ENSMUSP00000069371 | ENSMUSP00000133953 | E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. | Tripartite motif-containing 15. | 0.440 |
Trim23 | Trim42 | ENSMUSP00000069371 | ENSMUSP00000035026 | E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. | Tripartite motif-containing protein 42; Belongs to the TRIM/RBCC family. | 0.516 |
Trim23 | Trim56 | ENSMUSP00000069371 | ENSMUSP00000058109 | E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. | E3 ubiquitin-protein ligase TRIM56; E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity. In response to pathogen- and host-derived double- stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta. Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RAN [...] | 0.584 |
Trim23 | Trim69 | ENSMUSP00000069371 | ENSMUSP00000047627 | E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. | E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis; Belongs to the TRIM/RBCC family. | 0.469 |