node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Camkmt | Setmar | ENSMUSP00000092811 | ENSMUSP00000048225 | Calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of 'Lys-116' in calmodulin. | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.671 |
Camkmt | Smyd2 | ENSMUSP00000092811 | ENSMUSP00000027897 | Calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of 'Lys-116' in calmodulin. | N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.719 |
Cenpb | Setmar | ENSMUSP00000086938 | ENSMUSP00000048225 | Major centromere autoantigen B; Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.615 |
Naif1 | Pgbd5 | ENSMUSP00000048764 | ENSMUSP00000054788 | Nuclear apoptosis-inducing factor 1; Induces apoptosis. | PiggyBac transposable element-derived protein 5; Transposase that mediates sequence-specific genomic rearrangements. | 0.546 |
Naif1 | Setmar | ENSMUSP00000048764 | ENSMUSP00000048225 | Nuclear apoptosis-inducing factor 1; Induces apoptosis. | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.616 |
Naif1 | Tigd5 | ENSMUSP00000048764 | ENSMUSP00000141473 | Nuclear apoptosis-inducing factor 1; Induces apoptosis. | Tigger transposable element derived 5; Belongs to the tigger transposable element derived protein family. | 0.616 |
Pgbd5 | Naif1 | ENSMUSP00000054788 | ENSMUSP00000048764 | PiggyBac transposable element-derived protein 5; Transposase that mediates sequence-specific genomic rearrangements. | Nuclear apoptosis-inducing factor 1; Induces apoptosis. | 0.546 |
Pgbd5 | Setmar | ENSMUSP00000054788 | ENSMUSP00000048225 | PiggyBac transposable element-derived protein 5; Transposase that mediates sequence-specific genomic rearrangements. | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.692 |
Prpf19 | Setmar | ENSMUSP00000136858 | ENSMUSP00000048225 | Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.623 |
Setd3 | Setmar | ENSMUSP00000066413 | ENSMUSP00000048225 | Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin. Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.814 |
Setd3 | Smyd2 | ENSMUSP00000066413 | ENSMUSP00000027897 | Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin. Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. | N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.708 |
Setmar | Camkmt | ENSMUSP00000048225 | ENSMUSP00000092811 | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | Calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of 'Lys-116' in calmodulin. | 0.671 |
Setmar | Cenpb | ENSMUSP00000048225 | ENSMUSP00000086938 | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | Major centromere autoantigen B; Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. | 0.615 |
Setmar | Naif1 | ENSMUSP00000048225 | ENSMUSP00000048764 | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | Nuclear apoptosis-inducing factor 1; Induces apoptosis. | 0.616 |
Setmar | Pgbd5 | ENSMUSP00000048225 | ENSMUSP00000054788 | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | PiggyBac transposable element-derived protein 5; Transposase that mediates sequence-specific genomic rearrangements. | 0.692 |
Setmar | Prpf19 | ENSMUSP00000048225 | ENSMUSP00000136858 | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] | 0.623 |
Setmar | Setd3 | ENSMUSP00000048225 | ENSMUSP00000066413 | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin. Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. | 0.814 |
Setmar | Smyd2 | ENSMUSP00000048225 | ENSMUSP00000027897 | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily. | 0.667 |
Setmar | Sumf1 | ENSMUSP00000048225 | ENSMUSP00000032191 | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family. | 0.699 |
Setmar | Tigd5 | ENSMUSP00000048225 | ENSMUSP00000141473 | Histone-lysine N-methyltransferase SETMAR; Histone methyltransferase that methylates 'Lys-4' and 'Lys- 36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Belongs to the class V-like SAM-binding methyltransferase superfamily. | Tigger transposable element derived 5; Belongs to the tigger transposable element derived protein family. | 0.599 |