node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cchcr1 | Cdsn | ENSMUSP00000046612 | ENSMUSP00000048596 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.815 |
Cdsn | Cchcr1 | ENSMUSP00000048596 | ENSMUSP00000046612 | Corneodesmosin; Important for the epidermal barrier integrity. | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation. | 0.815 |
Cdsn | Dsc1 | ENSMUSP00000048596 | ENSMUSP00000042303 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | 0.989 |
Cdsn | Dsg1a | ENSMUSP00000048596 | ENSMUSP00000076393 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.986 |
Cdsn | Dsg1b | ENSMUSP00000048596 | ENSMUSP00000076026 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-1-beta; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.986 |
Cdsn | Dsg1c | ENSMUSP00000048596 | ENSMUSP00000054799 | Corneodesmosin; Important for the epidermal barrier integrity. | Desmoglein-1-gamma; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.986 |
Cdsn | Flg | ENSMUSP00000048596 | ENSMUSP00000142003 | Corneodesmosin; Important for the epidermal barrier integrity. | Filaggrin. | 0.743 |
Cdsn | Klk7 | ENSMUSP00000048596 | ENSMUSP00000032955 | Corneodesmosin; Important for the epidermal barrier integrity. | Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. | 0.749 |
Cdsn | Lor | ENSMUSP00000048596 | ENSMUSP00000052128 | Corneodesmosin; Important for the epidermal barrier integrity. | Loricrin; Major keratinocyte cell envelope protein. | 0.774 |
Cdsn | Tgm1 | ENSMUSP00000048596 | ENSMUSP00000128090 | Corneodesmosin; Important for the epidermal barrier integrity. | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). | 0.812 |
Cdsn | Tgm3 | ENSMUSP00000048596 | ENSMUSP00000105928 | Corneodesmosin; Important for the epidermal barrier integrity. | Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cros [...] | 0.739 |
Dsc1 | Cdsn | ENSMUSP00000042303 | ENSMUSP00000048596 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.989 |
Dsc1 | Dsg1a | ENSMUSP00000042303 | ENSMUSP00000076393 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.993 |
Dsc1 | Dsg1b | ENSMUSP00000042303 | ENSMUSP00000076026 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Desmoglein-1-beta; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.989 |
Dsc1 | Dsg1c | ENSMUSP00000042303 | ENSMUSP00000054799 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Desmoglein-1-gamma; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.985 |
Dsc1 | Flg | ENSMUSP00000042303 | ENSMUSP00000142003 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Filaggrin. | 0.780 |
Dsc1 | Klk7 | ENSMUSP00000042303 | ENSMUSP00000032955 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. | 0.767 |
Dsc1 | Lor | ENSMUSP00000042303 | ENSMUSP00000052128 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Loricrin; Major keratinocyte cell envelope protein. | 0.727 |
Dsc1 | Tgm3 | ENSMUSP00000042303 | ENSMUSP00000105928 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cros [...] | 0.494 |
Dsg1a | Cdsn | ENSMUSP00000076393 | ENSMUSP00000048596 | Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.986 |