node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clpb | Dnajc16 | ENSMUSP00000001884 | ENSMUSP00000048714 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; Belongs to the ClpA/ClpB family. | DnaJ homolog subfamily C member 16. | 0.539 |
Clpb | Hspa12b | ENSMUSP00000001884 | ENSMUSP00000096950 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; Belongs to the ClpA/ClpB family. | Heat shock 70 kDa protein 12B. | 0.710 |
Clpb | Hspa13 | ENSMUSP00000001884 | ENSMUSP00000048817 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; Belongs to the ClpA/ClpB family. | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Belongs to the heat shock protein 70 family. | 0.721 |
Clpb | Hspa4 | ENSMUSP00000001884 | ENSMUSP00000020630 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; Belongs to the ClpA/ClpB family. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.847 |
Clpb | Hsph1 | ENSMUSP00000001884 | ENSMUSP00000144413 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; Belongs to the ClpA/ClpB family. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.819 |
Clpb | Tsc1 | ENSMUSP00000001884 | ENSMUSP00000109500 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; Belongs to the ClpA/ClpB family. | Hamartin; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1. Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity. Competes with the activating co-chaperone AH [...] | 0.705 |
Crebrf | Dnajc16 | ENSMUSP00000059102 | ENSMUSP00000048714 | CREB3 regulatory factor; Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci (By similarity). | DnaJ homolog subfamily C member 16. | 0.571 |
Dnajc16 | Clpb | ENSMUSP00000048714 | ENSMUSP00000001884 | DnaJ homolog subfamily C member 16. | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; Belongs to the ClpA/ClpB family. | 0.539 |
Dnajc16 | Crebrf | ENSMUSP00000048714 | ENSMUSP00000059102 | DnaJ homolog subfamily C member 16. | CREB3 regulatory factor; Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci (By similarity). | 0.571 |
Dnajc16 | Dnajc27 | ENSMUSP00000048714 | ENSMUSP00000020986 | DnaJ homolog subfamily C member 16. | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family. | 0.577 |
Dnajc16 | Emc1 | ENSMUSP00000048714 | ENSMUSP00000137103 | DnaJ homolog subfamily C member 16. | ER membrane protein complex subunit 1. | 0.554 |
Dnajc16 | Hspa12b | ENSMUSP00000048714 | ENSMUSP00000096950 | DnaJ homolog subfamily C member 16. | Heat shock 70 kDa protein 12B. | 0.524 |
Dnajc16 | Hspa13 | ENSMUSP00000048714 | ENSMUSP00000048817 | DnaJ homolog subfamily C member 16. | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Belongs to the heat shock protein 70 family. | 0.516 |
Dnajc16 | Hspa4 | ENSMUSP00000048714 | ENSMUSP00000020630 | DnaJ homolog subfamily C member 16. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.516 |
Dnajc16 | Hsph1 | ENSMUSP00000048714 | ENSMUSP00000144413 | DnaJ homolog subfamily C member 16. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.577 |
Dnajc16 | Rbm22 | ENSMUSP00000048714 | ENSMUSP00000025506 | DnaJ homolog subfamily C member 16. | Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses; Belongs to the SLT11 family. | 0.560 |
Dnajc16 | Tsc1 | ENSMUSP00000048714 | ENSMUSP00000109500 | DnaJ homolog subfamily C member 16. | Hamartin; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1. Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity. Competes with the activating co-chaperone AH [...] | 0.551 |
Dnajc27 | Dnajc16 | ENSMUSP00000020986 | ENSMUSP00000048714 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family. | DnaJ homolog subfamily C member 16. | 0.577 |
Emc1 | Dnajc16 | ENSMUSP00000137103 | ENSMUSP00000048714 | ER membrane protein complex subunit 1. | DnaJ homolog subfamily C member 16. | 0.554 |
Emc1 | Hsph1 | ENSMUSP00000137103 | ENSMUSP00000144413 | ER membrane protein complex subunit 1. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.410 |