node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgef5 | Garem1 | ENSMUSP00000031750 | ENSMUSP00000048914 | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (By similarity). Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration. | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | 0.603 |
Axdnd1 | Garem1 | ENSMUSP00000148420 | ENSMUSP00000048914 | Axonemal dynein light chain domain-containing protein 1. | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | 0.511 |
Garem1 | Arhgef5 | ENSMUSP00000048914 | ENSMUSP00000031750 | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (By similarity). Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration. | 0.603 |
Garem1 | Axdnd1 | ENSMUSP00000048914 | ENSMUSP00000148420 | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | Axonemal dynein light chain domain-containing protein 1. | 0.511 |
Garem1 | Gdi1 | ENSMUSP00000048914 | ENSMUSP00000015435 | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | 0.516 |
Garem1 | Gdi2 | ENSMUSP00000048914 | ENSMUSP00000152454 | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | 0.516 |
Garem1 | Grb2 | ENSMUSP00000048914 | ENSMUSP00000021090 | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | 0.895 |
Garem1 | Nckap5 | ENSMUSP00000048914 | ENSMUSP00000108202 | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | NCK-associated protein 5. | 0.489 |
Garem1 | Rilpl2 | ENSMUSP00000048914 | ENSMUSP00000031347 | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | RILP-like protein 2; Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity). Belongs to the RILPL family. | 0.546 |
Garem1 | Themis2 | ENSMUSP00000048914 | ENSMUSP00000036945 | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | Protein THEMIS2; May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Belongs to the themis family. | 0.575 |
Garem1 | Themis3 | ENSMUSP00000048914 | ENSMUSP00000024914 | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | Protein THEMIS3. | 0.736 |
Garem1 | Zcchc3 | ENSMUSP00000048914 | ENSMUSP00000096813 | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | Zinc finger CCHC domain-containing protein 3; Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses. Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS. Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (By similarity). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and a [...] | 0.541 |
Gdi1 | Garem1 | ENSMUSP00000015435 | ENSMUSP00000048914 | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | 0.516 |
Gdi1 | Gdi2 | ENSMUSP00000015435 | ENSMUSP00000152454 | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | 0.599 |
Gdi2 | Garem1 | ENSMUSP00000152454 | ENSMUSP00000048914 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | 0.516 |
Gdi2 | Gdi1 | ENSMUSP00000152454 | ENSMUSP00000015435 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. | 0.599 |
Grb2 | Garem1 | ENSMUSP00000021090 | ENSMUSP00000048914 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | 0.895 |
Grb2 | Themis2 | ENSMUSP00000021090 | ENSMUSP00000036945 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family. | Protein THEMIS2; May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Belongs to the themis family. | 0.653 |
Nckap5 | Garem1 | ENSMUSP00000108202 | ENSMUSP00000048914 | NCK-associated protein 5. | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | 0.489 |
Rilpl2 | Garem1 | ENSMUSP00000031347 | ENSMUSP00000048914 | RILP-like protein 2; Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity). Belongs to the RILPL family. | GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family. | 0.546 |