node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cd46 | Dsg2 | ENSMUSP00000123931 | ENSMUSP00000057096 | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.773 |
Cd46 | Tbc1d8 | ENSMUSP00000123931 | ENSMUSP00000049967 | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s). | 0.619 |
Dsg2 | Cd46 | ENSMUSP00000057096 | ENSMUSP00000123931 | Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization. | 0.773 |
Dsg2 | Tbc1d8 | ENSMUSP00000057096 | ENSMUSP00000049967 | Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s). | 0.593 |
Gramd1a | Gramd1b | ENSMUSP00000001280 | ENSMUSP00000048126 | Protein Aster-A; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | Protein Aster-B; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to [...] | 0.424 |
Gramd1a | Tbc1d8 | ENSMUSP00000001280 | ENSMUSP00000049967 | Protein Aster-A; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s). | 0.692 |
Gramd1b | Gramd1a | ENSMUSP00000048126 | ENSMUSP00000001280 | Protein Aster-B; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to [...] | Protein Aster-A; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | 0.424 |
Gramd1b | Gramd1c | ENSMUSP00000048126 | ENSMUSP00000036739 | Protein Aster-B; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to [...] | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | 0.431 |
Gramd1b | Tbc1d8 | ENSMUSP00000048126 | ENSMUSP00000049967 | Protein Aster-B; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to [...] | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s). | 0.649 |
Gramd1c | Gramd1b | ENSMUSP00000036739 | ENSMUSP00000048126 | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | Protein Aster-B; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to [...] | 0.431 |
Gramd1c | Gramd2 | ENSMUSP00000036739 | ENSMUSP00000096258 | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | GRAM domain-containing protein 2A; Participates in the organization ofendoplasmic reticulum- plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum- plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). | 0.555 |
Gramd1c | Tbc1d8 | ENSMUSP00000036739 | ENSMUSP00000049967 | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s). | 0.662 |
Gramd2 | Gramd1c | ENSMUSP00000096258 | ENSMUSP00000036739 | GRAM domain-containing protein 2A; Participates in the organization ofendoplasmic reticulum- plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum- plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic retic [...] | 0.555 |
Gramd2 | Tbc1d8 | ENSMUSP00000096258 | ENSMUSP00000049967 | GRAM domain-containing protein 2A; Participates in the organization ofendoplasmic reticulum- plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum- plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s). | 0.675 |
Mtmr2 | Tbc1d8 | ENSMUSP00000034396 | ENSMUSP00000049967 | Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards pho sphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate. Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5- trisphosphate. Stabilizes SBF2/MTMR13 at the membranes. Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s). | 0.724 |
Tbc1d13 | Tbc1d21 | ENSMUSP00000048426 | ENSMUSP00000037525 | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | 0.710 |
Tbc1d13 | Tbc1d8 | ENSMUSP00000048426 | ENSMUSP00000049967 | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s). | 0.545 |
Tbc1d21 | Tbc1d13 | ENSMUSP00000037525 | ENSMUSP00000048426 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | 0.710 |
Tbc1d21 | Tbc1d8 | ENSMUSP00000037525 | ENSMUSP00000049967 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s). | 0.589 |
Tbc1d21 | Tbc1d9 | ENSMUSP00000037525 | ENSMUSP00000091093 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s). | 0.537 |