node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dusp19 | Styxl1 | ENSMUSP00000028384 | ENSMUSP00000051216 | Dual specificity protein phosphatase 19; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Serine/threonine/tyrosine-interacting-like 1. | 0.528 |
G3bp1 | Styxl1 | ENSMUSP00000018727 | ENSMUSP00000051216 | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | Serine/threonine/tyrosine-interacting-like 1. | 0.671 |
Lancl1 | Styxl1 | ENSMUSP00000109612 | ENSMUSP00000051216 | Glutathione S-transferase LANCL1; Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione (By similarity). Belongs to the LanC-like protein family. | Serine/threonine/tyrosine-interacting-like 1. | 0.549 |
Nudt10 | Nudt11 | ENSMUSP00000100071 | ENSMUSP00000100072 | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear; Belongs to the Nudix hydrolase family. DIPP subfamily. | Nudix (nucleoside diphosphate linked moiety X)-type motif 11. | 0.812 |
Nudt10 | Nxf3 | ENSMUSP00000100071 | ENSMUSP00000079730 | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear; Belongs to the Nudix hydrolase family. DIPP subfamily. | Nuclear RNA export factor 3. | 0.521 |
Nudt10 | Styxl1 | ENSMUSP00000100071 | ENSMUSP00000051216 | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear; Belongs to the Nudix hydrolase family. DIPP subfamily. | Serine/threonine/tyrosine-interacting-like 1. | 0.609 |
Nudt10 | Uhmk1 | ENSMUSP00000100071 | ENSMUSP00000027979 | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear; Belongs to the Nudix hydrolase family. DIPP subfamily. | Serine/threonine-protein kinase Kist; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.537 |
Nudt11 | Nudt10 | ENSMUSP00000100072 | ENSMUSP00000100071 | Nudix (nucleoside diphosphate linked moiety X)-type motif 11. | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear; Belongs to the Nudix hydrolase family. DIPP subfamily. | 0.812 |
Nudt11 | Nxf3 | ENSMUSP00000100072 | ENSMUSP00000079730 | Nudix (nucleoside diphosphate linked moiety X)-type motif 11. | Nuclear RNA export factor 3. | 0.529 |
Nudt11 | Styxl1 | ENSMUSP00000100072 | ENSMUSP00000051216 | Nudix (nucleoside diphosphate linked moiety X)-type motif 11. | Serine/threonine/tyrosine-interacting-like 1. | 0.611 |
Nudt11 | Uhmk1 | ENSMUSP00000100072 | ENSMUSP00000027979 | Nudix (nucleoside diphosphate linked moiety X)-type motif 11. | Serine/threonine-protein kinase Kist; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.538 |
Nxf3 | Nudt10 | ENSMUSP00000079730 | ENSMUSP00000100071 | Nuclear RNA export factor 3. | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear; Belongs to the Nudix hydrolase family. DIPP subfamily. | 0.521 |
Nxf3 | Nudt11 | ENSMUSP00000079730 | ENSMUSP00000100072 | Nuclear RNA export factor 3. | Nudix (nucleoside diphosphate linked moiety X)-type motif 11. | 0.529 |
Nxf3 | Styxl1 | ENSMUSP00000079730 | ENSMUSP00000051216 | Nuclear RNA export factor 3. | Serine/threonine/tyrosine-interacting-like 1. | 0.513 |
Nxf3 | Uhmk1 | ENSMUSP00000079730 | ENSMUSP00000027979 | Nuclear RNA export factor 3. | Serine/threonine-protein kinase Kist; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. | 0.401 |
Prkch | Styxl1 | ENSMUSP00000021527 | ENSMUSP00000051216 | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] | Serine/threonine/tyrosine-interacting-like 1. | 0.572 |
Styxl1 | Dusp19 | ENSMUSP00000051216 | ENSMUSP00000028384 | Serine/threonine/tyrosine-interacting-like 1. | Dual specificity protein phosphatase 19; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.528 |
Styxl1 | G3bp1 | ENSMUSP00000051216 | ENSMUSP00000018727 | Serine/threonine/tyrosine-interacting-like 1. | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] | 0.671 |
Styxl1 | Lancl1 | ENSMUSP00000051216 | ENSMUSP00000109612 | Serine/threonine/tyrosine-interacting-like 1. | Glutathione S-transferase LANCL1; Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione (By similarity). Belongs to the LanC-like protein family. | 0.549 |
Styxl1 | Nudt10 | ENSMUSP00000051216 | ENSMUSP00000100071 | Serine/threonine/tyrosine-interacting-like 1. | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear; Belongs to the Nudix hydrolase family. DIPP subfamily. | 0.609 |