STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pdcd2Programmed cell death protein 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. (343 aa)    
Predicted Functional Partners:
Rps2
40S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family.
   
 
 0.777
Fam120b
Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation.
   
  
 0.723
Psmb1
Proteasome subunit beta type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...]
   
  
 0.707
Pno1
RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. Belongs to the PNO1 family.
   
  
 0.676
Bccip
BRCA2 and CDKN1A-interacting protein; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity).
   
  
 0.663
Ltv1
Protein LTV1 homolog; Belongs to the LTV1 family.
   
  
 0.652
Pdcd2l
Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.
   
  
0.552
Zfp277
Zinc finger protein 277.
   
 
 0.532
Bysl
Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family.
   
  
 0.528
Tsr3
Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis.
   
  
 0.514
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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