node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Alkal1 | Fam78a | ENSMUSP00000137420 | ENSMUSP00000052826 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly. Belongs to the ALKAL family. | Protein FAM78A; Belongs to the FAM78 family. | 0.491 |
Ap2a1 | Fam78a | ENSMUSP00000127842 | ENSMUSP00000052826 | AP-2 complex subunit alpha-1; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold [...] | Protein FAM78A; Belongs to the FAM78 family. | 0.467 |
Ciart | Fam78a | ENSMUSP00000124943 | ENSMUSP00000052826 | Circadian-associated transcriptional repressor; Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK- ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. [...] | Protein FAM78A; Belongs to the FAM78 family. | 0.437 |
D430019H16Rik | Fam78a | ENSMUSP00000137376 | ENSMUSP00000052826 | RIKEN cDNA D430019H16 gene. | Protein FAM78A; Belongs to the FAM78 family. | 0.512 |
Ecel1 | Fam78a | ENSMUSP00000125096 | ENSMUSP00000052826 | Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides; Belongs to the peptidase M13 family. | Protein FAM78A; Belongs to the FAM78 family. | 0.418 |
Fam78a | Alkal1 | ENSMUSP00000052826 | ENSMUSP00000137420 | Protein FAM78A; Belongs to the FAM78 family. | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly. Belongs to the ALKAL family. | 0.491 |
Fam78a | Ap2a1 | ENSMUSP00000052826 | ENSMUSP00000127842 | Protein FAM78A; Belongs to the FAM78 family. | AP-2 complex subunit alpha-1; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold [...] | 0.467 |
Fam78a | Ciart | ENSMUSP00000052826 | ENSMUSP00000124943 | Protein FAM78A; Belongs to the FAM78 family. | Circadian-associated transcriptional repressor; Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK- ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. [...] | 0.437 |
Fam78a | D430019H16Rik | ENSMUSP00000052826 | ENSMUSP00000137376 | Protein FAM78A; Belongs to the FAM78 family. | RIKEN cDNA D430019H16 gene. | 0.512 |
Fam78a | Ecel1 | ENSMUSP00000052826 | ENSMUSP00000125096 | Protein FAM78A; Belongs to the FAM78 family. | Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides; Belongs to the peptidase M13 family. | 0.418 |
Fam78a | Gjd4 | ENSMUSP00000052826 | ENSMUSP00000035472 | Protein FAM78A; Belongs to the FAM78 family. | Gap junction delta-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | 0.512 |
Fam78a | Lims2 | ENSMUSP00000052826 | ENSMUSP00000025254 | Protein FAM78A; Belongs to the FAM78 family. | LIM and senescent cell antigen-like-containing domain protein 2; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. | 0.443 |
Fam78a | Phyhip | ENSMUSP00000052826 | ENSMUSP00000003561 | Protein FAM78A; Belongs to the FAM78 family. | Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system. | 0.487 |
Fam78a | Rasl11a | ENSMUSP00000052826 | ENSMUSP00000031646 | Protein FAM78A; Belongs to the FAM78 family. | Ras-like protein family member 11A; Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription. Belongs to the small GTPase superfamily. Ras family. | 0.460 |
Fam78a | Tcf23 | ENSMUSP00000052826 | ENSMUSP00000006818 | Protein FAM78A; Belongs to the FAM78 family. | Transcription factor 23; Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis. | 0.485 |
Gjd4 | Fam78a | ENSMUSP00000035472 | ENSMUSP00000052826 | Gap junction delta-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Protein FAM78A; Belongs to the FAM78 family. | 0.512 |
Gjd4 | Phyhip | ENSMUSP00000035472 | ENSMUSP00000003561 | Gap junction delta-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system. | 0.433 |
Gjd4 | Rasl11a | ENSMUSP00000035472 | ENSMUSP00000031646 | Gap junction delta-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Ras-like protein family member 11A; Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription. Belongs to the small GTPase superfamily. Ras family. | 0.401 |
Gjd4 | Tcf23 | ENSMUSP00000035472 | ENSMUSP00000006818 | Gap junction delta-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Transcription factor 23; Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis. | 0.413 |
Lims2 | Fam78a | ENSMUSP00000025254 | ENSMUSP00000052826 | LIM and senescent cell antigen-like-containing domain protein 2; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. | Protein FAM78A; Belongs to the FAM78 family. | 0.443 |