node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Alg3 | Fam131a | ENSMUSP00000045272 | ENSMUSP00000060194 | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol; Belongs to the glycosyltransferase 58 family. | Protein FAM131A; Belongs to the FAM131 family. | 0.526 |
Alg3 | Klhl6 | ENSMUSP00000045272 | ENSMUSP00000053023 | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol; Belongs to the glycosyltransferase 58 family. | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | 0.533 |
Card11 | Klhl6 | ENSMUSP00000082941 | ENSMUSP00000053023 | Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway (By similarity). | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | 0.521 |
Cul3 | Klhl6 | ENSMUSP00000130738 | ENSMUSP00000053023 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhi [...] | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | 0.622 |
Fam131a | Alg3 | ENSMUSP00000060194 | ENSMUSP00000045272 | Protein FAM131A; Belongs to the FAM131 family. | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol; Belongs to the glycosyltransferase 58 family. | 0.526 |
Fam131a | Klhl6 | ENSMUSP00000060194 | ENSMUSP00000053023 | Protein FAM131A; Belongs to the FAM131 family. | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | 0.515 |
Icos | Klhl6 | ENSMUSP00000099891 | ENSMUSP00000053023 | Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...] | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | 0.567 |
Klhdc2 | Klhl6 | ENSMUSP00000021362 | ENSMUSP00000053023 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding. | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | 0.565 |
Klhl6 | Alg3 | ENSMUSP00000053023 | ENSMUSP00000045272 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol; Belongs to the glycosyltransferase 58 family. | 0.533 |
Klhl6 | Card11 | ENSMUSP00000053023 | ENSMUSP00000082941 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway (By similarity). | 0.521 |
Klhl6 | Cul3 | ENSMUSP00000053023 | ENSMUSP00000130738 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhi [...] | 0.622 |
Klhl6 | Fam131a | ENSMUSP00000053023 | ENSMUSP00000060194 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | Protein FAM131A; Belongs to the FAM131 family. | 0.515 |
Klhl6 | Icos | ENSMUSP00000053023 | ENSMUSP00000099891 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...] | 0.567 |
Klhl6 | Klhdc2 | ENSMUSP00000053023 | ENSMUSP00000021362 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding. | 0.565 |
Klhl6 | Lcp1 | ENSMUSP00000053023 | ENSMUSP00000116271 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | Plastin-2; Actin-binding protein. Plays a role in the activation of T- cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. | 0.573 |
Klhl6 | Olfr1275 | ENSMUSP00000053023 | ENSMUSP00000149730 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | Olfactory receptor. | 0.538 |
Klhl6 | Ptpn14 | ENSMUSP00000053023 | ENSMUSP00000095051 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | Tyrosine-protein phosphatase non-receptor type 14; Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. | 0.524 |
Klhl6 | Sash3 | ENSMUSP00000053023 | ENSMUSP00000033427 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | 0.664 |
Lcp1 | Klhl6 | ENSMUSP00000116271 | ENSMUSP00000053023 | Plastin-2; Actin-binding protein. Plays a role in the activation of T- cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | 0.573 |
Olfr1275 | Klhl6 | ENSMUSP00000149730 | ENSMUSP00000053023 | Olfactory receptor. | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | 0.538 |