| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Adra2c | Ccl4 | ENSMUSP00000059705 | ENSMUSP00000019074 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | 0.916 |
| Adra2c | Ccl5 | ENSMUSP00000059705 | ENSMUSP00000039600 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells | 0.901 |
| Adra2c | Cxcl1 | ENSMUSP00000059705 | ENSMUSP00000031327 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | Growth-regulated alpha protein; Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity; Belongs to the intercrine alpha (chemokine CxC) family | 0.903 |
| Adra2c | Cxcl10 | ENSMUSP00000059705 | ENSMUSP00000047646 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | C-X-C motif chemokine 10; In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development; Belongs to the intercrine alpha (chemokine CxC) family | 0.903 |
| Adra2c | Cxcl12 | ENSMUSP00000059705 | ENSMUSP00000072800 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, an [...] | 0.916 |
| Adra2c | Cxcl2 | ENSMUSP00000059705 | ENSMUSP00000074885 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | C-X-C motif chemokine 2; Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst | 0.903 |
| Adra2c | Fpr2 | ENSMUSP00000059705 | ENSMUSP00000065799 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | Formyl peptide receptor 2; High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation | 0.900 |
| Adra2c | Hcar2 | ENSMUSP00000059705 | ENSMUSP00000054104 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | Hydroxycarboxylic acid receptor 2; Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and p [...] | 0.918 |
| Adra2c | Npb | ENSMUSP00000059705 | ENSMUSP00000101801 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | Neuropeptide B; Has an effect in food intake, on locomotor activity and has an analgesic effect, (in vivo pharmacological studies). May be involved in the regulation of neuroendocrine system, memory and learning (By similarity) | 0.918 |
| Adra2c | Pyy | ENSMUSP00000059705 | ENSMUSP00000017455 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | Peptide YY; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility | 0.911 |
| Ccl4 | Adra2c | ENSMUSP00000019074 | ENSMUSP00000059705 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins | 0.916 |
| Ccl4 | Ccl5 | ENSMUSP00000019074 | ENSMUSP00000039600 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells | 0.945 |
| Ccl4 | Cxcl1 | ENSMUSP00000019074 | ENSMUSP00000031327 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | Growth-regulated alpha protein; Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity; Belongs to the intercrine alpha (chemokine CxC) family | 0.985 |
| Ccl4 | Cxcl10 | ENSMUSP00000019074 | ENSMUSP00000047646 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | C-X-C motif chemokine 10; In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development; Belongs to the intercrine alpha (chemokine CxC) family | 0.993 |
| Ccl4 | Cxcl12 | ENSMUSP00000019074 | ENSMUSP00000072800 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, an [...] | 0.969 |
| Ccl4 | Cxcl2 | ENSMUSP00000019074 | ENSMUSP00000074885 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | C-X-C motif chemokine 2; Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst | 0.987 |
| Ccl4 | Fpr2 | ENSMUSP00000019074 | ENSMUSP00000065799 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | Formyl peptide receptor 2; High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation | 0.941 |
| Ccl4 | Hcar2 | ENSMUSP00000019074 | ENSMUSP00000054104 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | Hydroxycarboxylic acid receptor 2; Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and p [...] | 0.943 |
| Ccl4 | Npb | ENSMUSP00000019074 | ENSMUSP00000101801 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | Neuropeptide B; Has an effect in food intake, on locomotor activity and has an analgesic effect, (in vivo pharmacological studies). May be involved in the regulation of neuroendocrine system, memory and learning (By similarity) | 0.900 |
| Ccl4 | Pyy | ENSMUSP00000019074 | ENSMUSP00000017455 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties | Peptide YY; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility | 0.903 |
