node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Insl3 | Insl5 | ENSMUSP00000034261 | ENSMUSP00000102482 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | 0.968 |
Insl3 | Insl6 | ENSMUSP00000034261 | ENSMUSP00000054488 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. | 0.700 |
Insl3 | Rln1 | ENSMUSP00000034261 | ENSMUSP00000043376 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. | 0.977 |
Insl3 | Rln3 | ENSMUSP00000034261 | ENSMUSP00000051392 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. | 0.974 |
Insl3 | Rxfp1 | ENSMUSP00000034261 | ENSMUSP00000077611 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. | 0.995 |
Insl3 | Rxfp2 | ENSMUSP00000034261 | ENSMUSP00000067897 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.999 |
Insl3 | Rxfp3 | ENSMUSP00000034261 | ENSMUSP00000062741 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.977 |
Insl3 | Rxfp4 | ENSMUSP00000034261 | ENSMUSP00000058732 | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity). | 0.970 |
Insl5 | Insl3 | ENSMUSP00000102482 | ENSMUSP00000034261 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | 0.968 |
Insl5 | Insl6 | ENSMUSP00000102482 | ENSMUSP00000054488 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. | 0.751 |
Insl5 | Rln1 | ENSMUSP00000102482 | ENSMUSP00000043376 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. | 0.955 |
Insl5 | Rln3 | ENSMUSP00000102482 | ENSMUSP00000051392 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity); Belongs to the insulin family. | 0.919 |
Insl5 | Rxfp1 | ENSMUSP00000102482 | ENSMUSP00000077611 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. | 0.963 |
Insl5 | Rxfp2 | ENSMUSP00000102482 | ENSMUSP00000067897 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.960 |
Insl5 | Rxfp3 | ENSMUSP00000102482 | ENSMUSP00000062741 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.968 |
Insl5 | Rxfp4 | ENSMUSP00000102482 | ENSMUSP00000058732 | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity). | 0.990 |
Insl6 | Insl3 | ENSMUSP00000054488 | ENSMUSP00000034261 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. | Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). | 0.700 |
Insl6 | Insl5 | ENSMUSP00000054488 | ENSMUSP00000102482 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. | Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family. | 0.751 |
Insl6 | Pth2 | ENSMUSP00000054488 | ENSMUSP00000041047 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. | Tuberoinfundibular peptide of 39 residues; Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. | 0.468 |
Insl6 | Rln1 | ENSMUSP00000054488 | ENSMUSP00000043376 | Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family. | Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. | 0.713 |