node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
L3mbtl2 | Trim28 | ENSMUSP00000133967 | ENSMUSP00000005705 | Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.418 |
L3mbtl2 | Zkscan4 | ENSMUSP00000133967 | ENSMUSP00000054604 | Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). | Zinc finger with KRAB and SCAN domains 4. | 0.405 |
Lrrc37a | Zkscan4 | ENSMUSP00000121903 | ENSMUSP00000054604 | Leucine-rich repeat-containing 37A. | Zinc finger with KRAB and SCAN domains 4. | 0.454 |
Nkapl | Pgbd1 | ENSMUSP00000065168 | ENSMUSP00000097307 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | PiggyBac transposable element-derived 1. | 0.562 |
Nkapl | Zkscan4 | ENSMUSP00000065168 | ENSMUSP00000054604 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | Zinc finger with KRAB and SCAN domains 4. | 0.685 |
Pgbd1 | Nkapl | ENSMUSP00000097307 | ENSMUSP00000065168 | PiggyBac transposable element-derived 1. | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | 0.562 |
Pgbd1 | Zkscan4 | ENSMUSP00000097307 | ENSMUSP00000054604 | PiggyBac transposable element-derived 1. | Zinc finger with KRAB and SCAN domains 4. | 0.723 |
Tcaim | Zkscan4 | ENSMUSP00000049759 | ENSMUSP00000054604 | T-cell activation inhibitor, mitochondrial; May regulate T-cell apoptosis. | Zinc finger with KRAB and SCAN domains 4. | 0.542 |
Tmem161b | Zkscan4 | ENSMUSP00000055208 | ENSMUSP00000054604 | Transmembrane protein 161B. | Zinc finger with KRAB and SCAN domains 4. | 0.457 |
Trim28 | L3mbtl2 | ENSMUSP00000005705 | ENSMUSP00000133967 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). | 0.418 |
Trim28 | Zkscan4 | ENSMUSP00000005705 | ENSMUSP00000054604 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger with KRAB and SCAN domains 4. | 0.528 |
Zdhhc21 | Zkscan4 | ENSMUSP00000030110 | ENSMUSP00000054604 | Probable palmitoyltransferase ZDHHC21; Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity); Belongs to the DHHC palmitoyltransferase family. | Zinc finger with KRAB and SCAN domains 4. | 0.506 |
Zkscan4 | L3mbtl2 | ENSMUSP00000054604 | ENSMUSP00000133967 | Zinc finger with KRAB and SCAN domains 4. | Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). | 0.405 |
Zkscan4 | Lrrc37a | ENSMUSP00000054604 | ENSMUSP00000121903 | Zinc finger with KRAB and SCAN domains 4. | Leucine-rich repeat-containing 37A. | 0.454 |
Zkscan4 | Nkapl | ENSMUSP00000054604 | ENSMUSP00000065168 | Zinc finger with KRAB and SCAN domains 4. | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family. | 0.685 |
Zkscan4 | Pgbd1 | ENSMUSP00000054604 | ENSMUSP00000097307 | Zinc finger with KRAB and SCAN domains 4. | PiggyBac transposable element-derived 1. | 0.723 |
Zkscan4 | Tcaim | ENSMUSP00000054604 | ENSMUSP00000049759 | Zinc finger with KRAB and SCAN domains 4. | T-cell activation inhibitor, mitochondrial; May regulate T-cell apoptosis. | 0.542 |
Zkscan4 | Tmem161b | ENSMUSP00000054604 | ENSMUSP00000055208 | Zinc finger with KRAB and SCAN domains 4. | Transmembrane protein 161B. | 0.457 |
Zkscan4 | Trim28 | ENSMUSP00000054604 | ENSMUSP00000005705 | Zinc finger with KRAB and SCAN domains 4. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.528 |
Zkscan4 | Zdhhc21 | ENSMUSP00000054604 | ENSMUSP00000030110 | Zinc finger with KRAB and SCAN domains 4. | Probable palmitoyltransferase ZDHHC21; Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity); Belongs to the DHHC palmitoyltransferase family. | 0.506 |