node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Alkal2 | Skor1 | ENSMUSP00000070037 | ENSMUSP00000055037 | ALK and LTK ligand 2; Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation; Belongs to the FAM150 family. | SKI family transcriptional corepressor 1; Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. | 0.621 |
Btbd9 | Map2k5 | ENSMUSP00000127300 | ENSMUSP00000034920 | BTB/POZ domain-containing protein 9. | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | 0.743 |
Btbd9 | Meis1 | ENSMUSP00000127300 | ENSMUSP00000139219 | BTB/POZ domain-containing protein 9. | Homeobox protein Meis1; Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias; Belongs to the TALE/MEIS homeobox family. | 0.694 |
Btbd9 | Ptprd | ENSMUSP00000127300 | ENSMUSP00000133468 | BTB/POZ domain-containing protein 9. | Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | 0.679 |
Btbd9 | Ptprs | ENSMUSP00000127300 | ENSMUSP00000064048 | BTB/POZ domain-containing protein 9. | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain develop [...] | 0.538 |
Btbd9 | Skor1 | ENSMUSP00000127300 | ENSMUSP00000055037 | BTB/POZ domain-containing protein 9. | SKI family transcriptional corepressor 1; Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. | 0.783 |
Btbd9 | Tox3 | ENSMUSP00000127300 | ENSMUSP00000105250 | BTB/POZ domain-containing protein 9. | TOX high mobility group box family member 3; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen- responsive C3 promoter region (By similarity). | 0.666 |
Dnajc27 | Map2k5 | ENSMUSP00000020986 | ENSMUSP00000034920 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family. | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | 0.449 |
Dnajc27 | Skor1 | ENSMUSP00000020986 | ENSMUSP00000055037 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family. | SKI family transcriptional corepressor 1; Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. | 0.533 |
Lbx1 | Skor1 | ENSMUSP00000096997 | ENSMUSP00000055037 | Transcription factor LBX1; Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. | SKI family transcriptional corepressor 1; Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. | 0.637 |
Map2k5 | Btbd9 | ENSMUSP00000034920 | ENSMUSP00000127300 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | BTB/POZ domain-containing protein 9. | 0.743 |
Map2k5 | Dnajc27 | ENSMUSP00000034920 | ENSMUSP00000020986 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family. | 0.449 |
Map2k5 | Ptprd | ENSMUSP00000034920 | ENSMUSP00000133468 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | 0.524 |
Map2k5 | Ptprs | ENSMUSP00000034920 | ENSMUSP00000064048 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain develop [...] | 0.451 |
Map2k5 | Skor1 | ENSMUSP00000034920 | ENSMUSP00000055037 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | SKI family transcriptional corepressor 1; Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. | 0.890 |
Meis1 | Btbd9 | ENSMUSP00000139219 | ENSMUSP00000127300 | Homeobox protein Meis1; Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias; Belongs to the TALE/MEIS homeobox family. | BTB/POZ domain-containing protein 9. | 0.694 |
Meis1 | Skor1 | ENSMUSP00000139219 | ENSMUSP00000055037 | Homeobox protein Meis1; Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias; Belongs to the TALE/MEIS homeobox family. | SKI family transcriptional corepressor 1; Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. | 0.557 |
Ptprd | Btbd9 | ENSMUSP00000133468 | ENSMUSP00000127300 | Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | BTB/POZ domain-containing protein 9. | 0.679 |
Ptprd | Map2k5 | ENSMUSP00000133468 | ENSMUSP00000034920 | Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. | 0.524 |
Ptprd | Skor1 | ENSMUSP00000133468 | ENSMUSP00000055037 | Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. | SKI family transcriptional corepressor 1; Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. | 0.637 |