node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc150 | Tmem88 | ENSMUSP00000027128 | ENSMUSP00000055528 | Coiled-coil domain-containing protein 150. | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | 0.437 |
Dvl1 | Tmem88 | ENSMUSP00000030948 | ENSMUSP00000055528 | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Belongs [...] | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | 0.890 |
Kdm6b | Tmem88 | ENSMUSP00000091620 | ENSMUSP00000055528 | Lysine-specific demethylase 6B; Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expressio [...] | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | 0.476 |
Tmem178 | Tmem88 | ENSMUSP00000025092 | ENSMUSP00000055528 | Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | 0.571 |
Tmem178 | Tmem94 | ENSMUSP00000025092 | ENSMUSP00000091440 | Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. | Transmembrane protein 94. | 0.694 |
Tmem207 | Tmem25 | ENSMUSP00000127563 | ENSMUSP00000002100 | Transmembrane protein 207. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.640 |
Tmem207 | Tmem88 | ENSMUSP00000127563 | ENSMUSP00000055528 | Transmembrane protein 207. | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | 0.467 |
Tmem25 | Tmem207 | ENSMUSP00000002100 | ENSMUSP00000127563 | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | Transmembrane protein 207. | 0.640 |
Tmem25 | Tmem88 | ENSMUSP00000002100 | ENSMUSP00000055528 | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | 0.427 |
Tmem45a | Tmem88 | ENSMUSP00000023435 | ENSMUSP00000055528 | Transmembrane protein 45A. | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | 0.433 |
Tmem88 | Ccdc150 | ENSMUSP00000055528 | ENSMUSP00000027128 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | Coiled-coil domain-containing protein 150. | 0.437 |
Tmem88 | Dvl1 | ENSMUSP00000055528 | ENSMUSP00000030948 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Belongs [...] | 0.890 |
Tmem88 | Kdm6b | ENSMUSP00000055528 | ENSMUSP00000091620 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | Lysine-specific demethylase 6B; Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expressio [...] | 0.476 |
Tmem88 | Tmem178 | ENSMUSP00000055528 | ENSMUSP00000025092 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. | 0.571 |
Tmem88 | Tmem207 | ENSMUSP00000055528 | ENSMUSP00000127563 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | Transmembrane protein 207. | 0.467 |
Tmem88 | Tmem25 | ENSMUSP00000055528 | ENSMUSP00000002100 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. | 0.427 |
Tmem88 | Tmem45a | ENSMUSP00000055528 | ENSMUSP00000023435 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | Transmembrane protein 45A. | 0.433 |
Tmem88 | Tmem94 | ENSMUSP00000055528 | ENSMUSP00000091440 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | Transmembrane protein 94. | 0.647 |
Tmem88 | Tmem98 | ENSMUSP00000055528 | ENSMUSP00000042825 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). | 0.428 |
Tmem88 | Vwc2 | ENSMUSP00000055528 | ENSMUSP00000105303 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family. | Brorin; BMP antagonist which may play a role in neural development. Promotes cell adhesion. | 0.493 |