STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sprr3Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Belongs to the cornifin (SPRR) family. (238 aa)    
Predicted Functional Partners:
Krt13
Keratin, type I cytoskeletal 13.
   
  
 0.817
Krt4
Keratin, type II cytoskeletal 4.
   
  
 0.804
Cnfn
Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
   
  
 0.767
Sprr2a1
Small proline-rich protein 2A3; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity). Belongs to the cornifin (SPRR) family.
   
  
 0.726
Crct1
Cysteine-rich C-terminal 1.
   
  
 0.714
Lce3a
Late cornified envelope 3A.
   
  
 0.712
Sprr4
Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification (By similarity).
      
 0.710
Tgm3
Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cros [...]
   
  
 0.708
Lor
Loricrin; Major keratinocyte cell envelope protein.
   
  
 0.704
Lce3c
Late cornified envelope 3C.
   
  
 0.699
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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