STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mex3dRNA-binding protein MEX3D; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. (718 aa)    
Predicted Functional Partners:
Lmbrd2
G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1.
   
  
 0.558
Fam214a
Protein FAM214A.
      
 0.482
Samd4b
Protein Smaug homolog 2; Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A (By similarity); Belongs to the SMAUG family.
   
  
 0.469
Tmem141
Transmembrane protein 141.
      
 0.466
Rsl24d1
Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity).
      
 0.464
Tmem117
Transmembrane protein 117; Involved in endoplasmic reticulum (ER) stress-induced cell death pathway; Belongs to the TMEM117 family.
      
 0.461
Ddx59
Probable ATP-dependent RNA helicase DDX59; Belongs to the DEAD box helicase family. DDX59 subfamily.
   
 
 0.460
Ttc37
Tetratricopeptide repeat domain 37.
      
 0.455
Zfp646
Zinc finger protein 646; May be involved in transcriptional regulation.
   
  
 0.449
Btbd2
BTB (POZ) domain-containing 2.
   
  
 0.442
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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