node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aip | Gpr101 | ENSMUSP00000113807 | ENSMUSP00000058183 | AH receptor-interacting protein; May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.610 |
Asb12 | Gpr101 | ENSMUSP00000033549 | ENSMUSP00000058183 | Ankyrin repeat and SOCS box protein 12; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.505 |
Cbln4 | Gpr101 | ENSMUSP00000085263 | ENSMUSP00000058183 | Cerebellin-4; Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for the formation and maintenance of inhibitory GABAergic synapses. Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons. May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors. May play a role in CBLN3 export from the endoplasmic reticulum and secretion. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.495 |
Cbln4 | Gpr26 | ENSMUSP00000085263 | ENSMUSP00000041664 | Cerebellin-4; Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for the formation and maintenance of inhibitory GABAergic synapses. Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons. May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors. May play a role in CBLN3 export from the endoplasmic reticulum and secretion. | G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.466 |
Ghrh | Gnas | ENSMUSP00000029172 | ENSMUSP00000140174 | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. | 0.810 |
Ghrh | Gnrh1 | ENSMUSP00000029172 | ENSMUSP00000106724 | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | 0.720 |
Ghrh | Gpr101 | ENSMUSP00000029172 | ENSMUSP00000058183 | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.484 |
Gnas | Ghrh | ENSMUSP00000140174 | ENSMUSP00000029172 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | 0.810 |
Gnas | Gpr101 | ENSMUSP00000140174 | ENSMUSP00000058183 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.613 |
Gnrh1 | Ghrh | ENSMUSP00000106724 | ENSMUSP00000029172 | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | 0.720 |
Gnrh1 | Gpr101 | ENSMUSP00000106724 | ENSMUSP00000058183 | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.579 |
Gpr101 | Aip | ENSMUSP00000058183 | ENSMUSP00000113807 | Probable G-protein coupled receptor 101; Orphan receptor. | AH receptor-interacting protein; May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. | 0.610 |
Gpr101 | Asb12 | ENSMUSP00000058183 | ENSMUSP00000033549 | Probable G-protein coupled receptor 101; Orphan receptor. | Ankyrin repeat and SOCS box protein 12; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.505 |
Gpr101 | Cbln4 | ENSMUSP00000058183 | ENSMUSP00000085263 | Probable G-protein coupled receptor 101; Orphan receptor. | Cerebellin-4; Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for the formation and maintenance of inhibitory GABAergic synapses. Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons. May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors. May play a role in CBLN3 export from the endoplasmic reticulum and secretion. | 0.495 |
Gpr101 | Ghrh | ENSMUSP00000058183 | ENSMUSP00000029172 | Probable G-protein coupled receptor 101; Orphan receptor. | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family. | 0.484 |
Gpr101 | Gnas | ENSMUSP00000058183 | ENSMUSP00000140174 | Probable G-protein coupled receptor 101; Orphan receptor. | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms. | 0.613 |
Gpr101 | Gnrh1 | ENSMUSP00000058183 | ENSMUSP00000106724 | Probable G-protein coupled receptor 101; Orphan receptor. | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | 0.579 |
Gpr101 | Gpr162 | ENSMUSP00000058183 | ENSMUSP00000145267 | Probable G-protein coupled receptor 101; Orphan receptor. | Probable G-protein coupled receptor 162; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.514 |
Gpr101 | Gpr26 | ENSMUSP00000058183 | ENSMUSP00000041664 | Probable G-protein coupled receptor 101; Orphan receptor. | G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.538 |
Gpr101 | Gpr62 | ENSMUSP00000058183 | ENSMUSP00000129055 | Probable G-protein coupled receptor 101; Orphan receptor. | G-protein coupled receptor 62; Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). | 0.534 |