node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc163 | Map9 | ENSMUSP00000102072 | ENSMUSP00000088535 | Coiled-coil domain-containing 163. | Microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules (By similarity). | 0.510 |
Ccdc163 | Sapcd2 | ENSMUSP00000102072 | ENSMUSP00000028329 | Coiled-coil domain-containing 163. | Suppressor APC domain-containing protein 2; Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions. Negatively regulates the mitotic apical cortex localization of GPSM2 (By similarity). Involved also in positive regulation of cell proliferation and tumor cell growth (By similarity). | 0.433 |
Ccdc163 | Tmem82 | ENSMUSP00000102072 | ENSMUSP00000058412 | Coiled-coil domain-containing 163. | Transmembrane protein 82. | 0.754 |
Cep41 | Cep78 | ENSMUSP00000031810 | ENSMUSP00000037596 | Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis. | 0.545 |
Cep41 | Spata3 | ENSMUSP00000031810 | ENSMUSP00000050509 | Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. | Spermatogenesis-associated protein 3. | 0.511 |
Cep41 | Tmem82 | ENSMUSP00000031810 | ENSMUSP00000058412 | Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. | Transmembrane protein 82. | 0.607 |
Cep78 | Cep41 | ENSMUSP00000037596 | ENSMUSP00000031810 | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis. | Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium. | 0.545 |
Cep78 | Sh3bp4 | ENSMUSP00000037596 | ENSMUSP00000067581 | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis. | SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity). | 0.472 |
Cep78 | Spata3 | ENSMUSP00000037596 | ENSMUSP00000050509 | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis. | Spermatogenesis-associated protein 3. | 0.613 |
Cep78 | Tmem82 | ENSMUSP00000037596 | ENSMUSP00000058412 | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis. | Transmembrane protein 82. | 0.650 |
Fam131c | Slc25a34 | ENSMUSP00000006380 | ENSMUSP00000039188 | Family with sequence similarity 131, member C. | Solute carrier family 25 member 34; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.501 |
Fam131c | Tmem82 | ENSMUSP00000006380 | ENSMUSP00000058412 | Family with sequence similarity 131, member C. | Transmembrane protein 82. | 0.633 |
Fblim1 | Tmem82 | ENSMUSP00000006381 | ENSMUSP00000058412 | Filamin-binding LIM protein 1; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). | Transmembrane protein 82. | 0.630 |
Map9 | Ccdc163 | ENSMUSP00000088535 | ENSMUSP00000102072 | Microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules (By similarity). | Coiled-coil domain-containing 163. | 0.510 |
Map9 | Tmem82 | ENSMUSP00000088535 | ENSMUSP00000058412 | Microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules (By similarity). | Transmembrane protein 82. | 0.674 |
Sapcd2 | Ccdc163 | ENSMUSP00000028329 | ENSMUSP00000102072 | Suppressor APC domain-containing protein 2; Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions. Negatively regulates the mitotic apical cortex localization of GPSM2 (By similarity). Involved also in positive regulation of cell proliferation and tumor cell growth (By similarity). | Coiled-coil domain-containing 163. | 0.433 |
Sapcd2 | Tmem82 | ENSMUSP00000028329 | ENSMUSP00000058412 | Suppressor APC domain-containing protein 2; Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions. Negatively regulates the mitotic apical cortex localization of GPSM2 (By similarity). Involved also in positive regulation of cell proliferation and tumor cell growth (By similarity). | Transmembrane protein 82. | 0.609 |
Sh3bp4 | Cep78 | ENSMUSP00000067581 | ENSMUSP00000037596 | SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity). | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis. | 0.472 |
Sh3bp4 | Spata3 | ENSMUSP00000067581 | ENSMUSP00000050509 | SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity). | Spermatogenesis-associated protein 3. | 0.575 |
Sh3bp4 | Tmem82 | ENSMUSP00000067581 | ENSMUSP00000058412 | SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity). | Transmembrane protein 82. | 0.613 |