node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bclaf1 | St7l | ENSMUSP00000043583 | ENSMUSP00000058455 | Bcl-2-associated transcription factor 1; Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity). | Suppressor of tumorigenicity 7 protein-like. | 0.420 |
Capza1 | St7l | ENSMUSP00000102381 | ENSMUSP00000058455 | F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. | Suppressor of tumorigenicity 7 protein-like. | 0.427 |
Fign | St7l | ENSMUSP00000122855 | ENSMUSP00000058455 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity). | Suppressor of tumorigenicity 7 protein-like. | 0.480 |
Fxyd2 | St7l | ENSMUSP00000035429 | ENSMUSP00000058455 | Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. | Suppressor of tumorigenicity 7 protein-like. | 0.524 |
Fxyd2 | Taok2 | ENSMUSP00000035429 | ENSMUSP00000112963 | Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.511 |
Fxyd2 | Tspyl2 | ENSMUSP00000035429 | ENSMUSP00000046782 | Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. | Testis-specific Y-encoded-like protein 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. | 0.402 |
Gin1 | St7l | ENSMUSP00000108464 | ENSMUSP00000058455 | Gypsy retrotransposon integrase-like protein 1. | Suppressor of tumorigenicity 7 protein-like. | 0.418 |
Rint1 | St7l | ENSMUSP00000030852 | ENSMUSP00000058455 | RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control (By similarity). Belongs to the RINT1 family. | Suppressor of tumorigenicity 7 protein-like. | 0.792 |
St7l | Bclaf1 | ENSMUSP00000058455 | ENSMUSP00000043583 | Suppressor of tumorigenicity 7 protein-like. | Bcl-2-associated transcription factor 1; Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity). | 0.420 |
St7l | Capza1 | ENSMUSP00000058455 | ENSMUSP00000102381 | Suppressor of tumorigenicity 7 protein-like. | F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. | 0.427 |
St7l | Fign | ENSMUSP00000058455 | ENSMUSP00000122855 | Suppressor of tumorigenicity 7 protein-like. | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity). | 0.480 |
St7l | Fxyd2 | ENSMUSP00000058455 | ENSMUSP00000035429 | Suppressor of tumorigenicity 7 protein-like. | Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. | 0.524 |
St7l | Gin1 | ENSMUSP00000058455 | ENSMUSP00000108464 | Suppressor of tumorigenicity 7 protein-like. | Gypsy retrotransposon integrase-like protein 1. | 0.418 |
St7l | Rint1 | ENSMUSP00000058455 | ENSMUSP00000030852 | Suppressor of tumorigenicity 7 protein-like. | RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control (By similarity). Belongs to the RINT1 family. | 0.792 |
St7l | Taok2 | ENSMUSP00000058455 | ENSMUSP00000112963 | Suppressor of tumorigenicity 7 protein-like. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.499 |
St7l | Tspyl2 | ENSMUSP00000058455 | ENSMUSP00000046782 | Suppressor of tumorigenicity 7 protein-like. | Testis-specific Y-encoded-like protein 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. | 0.466 |
Taok2 | Fxyd2 | ENSMUSP00000112963 | ENSMUSP00000035429 | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. | 0.511 |
Taok2 | St7l | ENSMUSP00000112963 | ENSMUSP00000058455 | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | Suppressor of tumorigenicity 7 protein-like. | 0.499 |
Taok2 | Tspyl2 | ENSMUSP00000112963 | ENSMUSP00000046782 | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | Testis-specific Y-encoded-like protein 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. | 0.401 |
Tspyl2 | Fxyd2 | ENSMUSP00000046782 | ENSMUSP00000035429 | Testis-specific Y-encoded-like protein 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. | Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. | 0.402 |