node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clrn3 | Kctd9 | ENSMUSP00000056245 | ENSMUSP00000114489 | Clarin-3. | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. | 0.515 |
Clrn3 | Rnf24 | ENSMUSP00000056245 | ENSMUSP00000058630 | Clarin-3. | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | 0.516 |
Clrn3 | Ubox5 | ENSMUSP00000056245 | ENSMUSP00000028761 | Clarin-3. | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | 0.475 |
Dhx35 | Rnf24 | ENSMUSP00000029186 | ENSMUSP00000058630 | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | 0.483 |
Fkbp1a | Rnf24 | ENSMUSP00000037206 | ENSMUSP00000058630 | Peptidyl-prolyl cis-trans isomerase FKBP1A; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP [...] | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | 0.453 |
Fkbp1a | Rps27a | ENSMUSP00000037206 | ENSMUSP00000099909 | Peptidyl-prolyl cis-trans isomerase FKBP1A; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP [...] | Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] | 0.509 |
Fkbp1a | Trpc6 | ENSMUSP00000037206 | ENSMUSP00000057965 | Peptidyl-prolyl cis-trans isomerase FKBP1A; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP [...] | Short transient receptor potential channel 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. | 0.718 |
Kctd9 | Clrn3 | ENSMUSP00000114489 | ENSMUSP00000056245 | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. | Clarin-3. | 0.515 |
Kctd9 | Rnf24 | ENSMUSP00000114489 | ENSMUSP00000058630 | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | 0.521 |
Kctd9 | Ubox5 | ENSMUSP00000114489 | ENSMUSP00000028761 | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | 0.519 |
Pank2 | Rnf24 | ENSMUSP00000119606 | ENSMUSP00000058630 | Pantothenate kinase 2 (Hallervorden-Spatz syndrome). | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | 0.522 |
Rnf24 | Clrn3 | ENSMUSP00000058630 | ENSMUSP00000056245 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Clarin-3. | 0.516 |
Rnf24 | Dhx35 | ENSMUSP00000058630 | ENSMUSP00000029186 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | DEAH (Asp-Glu-Ala-His) box polypeptide 35. | 0.483 |
Rnf24 | Fkbp1a | ENSMUSP00000058630 | ENSMUSP00000037206 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Peptidyl-prolyl cis-trans isomerase FKBP1A; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP [...] | 0.453 |
Rnf24 | Kctd9 | ENSMUSP00000058630 | ENSMUSP00000114489 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. | 0.521 |
Rnf24 | Pank2 | ENSMUSP00000058630 | ENSMUSP00000119606 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Pantothenate kinase 2 (Hallervorden-Spatz syndrome). | 0.522 |
Rnf24 | Rps27a | ENSMUSP00000058630 | ENSMUSP00000099909 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] | 0.498 |
Rnf24 | Rwdd1 | ENSMUSP00000058630 | ENSMUSP00000019917 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation. Belongs to the RWDD1/GIR2 family. | 0.500 |
Rnf24 | Trpc6 | ENSMUSP00000058630 | ENSMUSP00000057965 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Short transient receptor potential channel 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. | 0.722 |
Rnf24 | Ubox5 | ENSMUSP00000058630 | ENSMUSP00000028761 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | 0.506 |