STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Prss33Serine protease 33; Serine protease that has amidolytic activity, cleaving its substrates before Arg residues. (277 aa)    
Predicted Functional Partners:
Trmt9b
Probable tRNA methyltransferase 9B; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity); Belongs to the methyltransferase superfamily.
    
 
 0.579
Tango2
Transport and Golgi organization 2 homolog.
   
  
 0.521
Prph
Peripherin; Class-III neuronal intermediate filament protein; Belongs to the intermediate filament family.
      
 0.519
Lonrf1
LON peptidase N-terminal domain and RING finger protein 1.
    
 
 0.498
Zgrf1
Protein ZGRF1.
      
 0.497
Eme2
Probable crossover junction endonuclease EME2; Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures.
    
 
 0.487
Trmt13
tRNA:m(4)X modification enzyme TRM13 homolog; tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). Belongs to the methyltransferase TRM13 family.
      
 0.470
Mmp24
Processed matrix metalloproteinase-24; Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell- cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to [...]
   
 
 0.457
Sec14l5
SEC14-like 5 (S. cerevisiae).
   
 
 0.450
Purg
Purine-rich element-binding protein gamma.
      
 0.449
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (26%) [HD]