node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ang5 | Vill | ENSMUSP00000067008 | ENSMUSP00000061731 | Angiogenin-3; May promote vascularization of normal and malignant tissues (By similarity). Has low ribonuclease activity (in vitro). | Villin-like protein; Possible tumor suppressor. | 0.444 |
Cog3 | Cog6 | ENSMUSP00000045016 | ENSMUSP00000048603 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | 0.999 |
Cog3 | Cog8 | ENSMUSP00000045016 | ENSMUSP00000093173 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
Cog3 | Vil1 | ENSMUSP00000045016 | ENSMUSP00000027366 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] | 0.487 |
Cog3 | Vill | ENSMUSP00000045016 | ENSMUSP00000061731 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | Villin-like protein; Possible tumor suppressor. | 0.487 |
Cog6 | Cog3 | ENSMUSP00000048603 | ENSMUSP00000045016 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
Cog6 | Cog8 | ENSMUSP00000048603 | ENSMUSP00000093173 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | 0.999 |
Cog6 | Vil1 | ENSMUSP00000048603 | ENSMUSP00000027366 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] | 0.505 |
Cog6 | Vill | ENSMUSP00000048603 | ENSMUSP00000061731 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | Villin-like protein; Possible tumor suppressor. | 0.505 |
Cog8 | Cog3 | ENSMUSP00000093173 | ENSMUSP00000045016 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.999 |
Cog8 | Cog6 | ENSMUSP00000093173 | ENSMUSP00000048603 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. | 0.999 |
Cog8 | Vil1 | ENSMUSP00000093173 | ENSMUSP00000027366 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] | 0.532 |
Cog8 | Vill | ENSMUSP00000093173 | ENSMUSP00000061731 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function. | Villin-like protein; Possible tumor suppressor. | 0.532 |
Ctdspl | Vill | ENSMUSP00000072852 | ENSMUSP00000061731 | CTD small phosphatase-like protein; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). | Villin-like protein; Possible tumor suppressor. | 0.592 |
Mif4gd | Stard9 | ENSMUSP00000102116 | ENSMUSP00000136055 | MIF4G domain-containing protein; Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity). Belongs to the MIF4GD family. | StAR-related lipid transfer protein 9; Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM) (By similarity). | 0.451 |
Mif4gd | Vill | ENSMUSP00000102116 | ENSMUSP00000061731 | MIF4G domain-containing protein; Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity). Belongs to the MIF4GD family. | Villin-like protein; Possible tumor suppressor. | 0.509 |
Prr7 | Vill | ENSMUSP00000046776 | ENSMUSP00000061731 | Proline-rich protein 7; Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (By similarity). Might play a redundant role in the regulation of T cell receptor signaling. Might promote apoptosis in T cells (By similarity). | Villin-like protein; Possible tumor suppressor. | 0.472 |
Stard9 | Mif4gd | ENSMUSP00000136055 | ENSMUSP00000102116 | StAR-related lipid transfer protein 9; Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM) (By similarity). | MIF4G domain-containing protein; Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity). Belongs to the MIF4GD family. | 0.451 |
Stard9 | Vill | ENSMUSP00000136055 | ENSMUSP00000061731 | StAR-related lipid transfer protein 9; Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM) (By similarity). | Villin-like protein; Possible tumor suppressor. | 0.481 |
Svil | Vil1 | ENSMUSP00000115078 | ENSMUSP00000027366 | Supervillin; [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] | 0.559 |