node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abi1 | Liph | ENSMUSP00000118491 | ENSMUSP00000062310 | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF- induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine n [...] | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | 0.436 |
Dsg4 | Liph | ENSMUSP00000019426 | ENSMUSP00000062310 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | 0.500 |
Dsg4 | Lpar6 | ENSMUSP00000019426 | ENSMUSP00000042327 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). | 0.702 |
Fbxo6 | Liph | ENSMUSP00000101331 | ENSMUSP00000062310 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolde [...] | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | 0.449 |
Fbxo6 | Obp2a | ENSMUSP00000101331 | ENSMUSP00000076851 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolde [...] | Odorant-binding protein 2a; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis. | 0.416 |
Gm13102 | Liph | ENSMUSP00000101387 | ENSMUSP00000062310 | Predicted gene 13102. | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | 0.481 |
Liph | Abi1 | ENSMUSP00000062310 | ENSMUSP00000118491 | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF- induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine n [...] | 0.436 |
Liph | Dsg4 | ENSMUSP00000062310 | ENSMUSP00000019426 | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | 0.500 |
Liph | Fbxo6 | ENSMUSP00000062310 | ENSMUSP00000101331 | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolde [...] | 0.449 |
Liph | Gm13102 | ENSMUSP00000062310 | ENSMUSP00000101387 | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | Predicted gene 13102. | 0.481 |
Liph | Lpar3 | ENSMUSP00000062310 | ENSMUSP00000037712 | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | Lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. | 0.524 |
Liph | Lpar6 | ENSMUSP00000062310 | ENSMUSP00000042327 | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). | 0.683 |
Liph | Obp2a | ENSMUSP00000062310 | ENSMUSP00000076851 | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | Odorant-binding protein 2a; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis. | 0.525 |
Liph | Pou2f3 | ENSMUSP00000062310 | ENSMUSP00000135115 | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'); Belongs to the POU transcription factor family. Class-2 subfamily. | 0.470 |
Liph | Tmem41a | ENSMUSP00000062310 | ENSMUSP00000023562 | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | Transmembrane protein 41A; Belongs to the TMEM41 family. | 0.536 |
Lpar3 | Liph | ENSMUSP00000037712 | ENSMUSP00000062310 | Lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | 0.524 |
Lpar3 | Lpar6 | ENSMUSP00000037712 | ENSMUSP00000042327 | Lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). | 0.987 |
Lpar6 | Dsg4 | ENSMUSP00000042327 | ENSMUSP00000019426 | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. | 0.702 |
Lpar6 | Liph | ENSMUSP00000042327 | ENSMUSP00000062310 | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce lysophosphatidic acid (LPA); Belongs to the AB hydrolase superfamily. Lipase family. | 0.683 |
Lpar6 | Lpar3 | ENSMUSP00000042327 | ENSMUSP00000037712 | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity). | Lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. | 0.987 |