node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adgb | Ccdc149 | ENSMUSP00000045452 | ENSMUSP00000062411 | Androglobin; Belongs to the peptidase C2 family. | Coiled-coil domain-containing 149. | 0.514 |
Adgb | Iqca | ENSMUSP00000045452 | ENSMUSP00000108717 | Androglobin; Belongs to the peptidase C2 family. | Dynein regulatory complex protein 11; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the AAA ATPase family. DRC11 subfamily. | 0.558 |
Adgb | Slc36a1 | ENSMUSP00000045452 | ENSMUSP00000104500 | Androglobin; Belongs to the peptidase C2 family. | Proton-coupled amino acid transporter 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognizes their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid. | 0.516 |
Ccdc125 | Ccdc149 | ENSMUSP00000058484 | ENSMUSP00000062411 | Coiled-coil domain-containing protein 125; May be involved in the regulation of cell migration. | Coiled-coil domain-containing 149. | 0.516 |
Ccdc149 | Adgb | ENSMUSP00000062411 | ENSMUSP00000045452 | Coiled-coil domain-containing 149. | Androglobin; Belongs to the peptidase C2 family. | 0.514 |
Ccdc149 | Ccdc125 | ENSMUSP00000062411 | ENSMUSP00000058484 | Coiled-coil domain-containing 149. | Coiled-coil domain-containing protein 125; May be involved in the regulation of cell migration. | 0.516 |
Ccdc149 | Dlgap1 | ENSMUSP00000062411 | ENSMUSP00000122896 | Coiled-coil domain-containing 149. | Disks large-associated protein 1; Part of the postsynaptic scaffold in neuronal cells; Belongs to the SAPAP family. | 0.583 |
Ccdc149 | Iqca | ENSMUSP00000062411 | ENSMUSP00000108717 | Coiled-coil domain-containing 149. | Dynein regulatory complex protein 11; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the AAA ATPase family. DRC11 subfamily. | 0.514 |
Ccdc149 | Myo10 | ENSMUSP00000062411 | ENSMUSP00000106087 | Coiled-coil domain-containing 149. | Unconventional myosin-X; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments (By similarity). Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippo [...] | 0.587 |
Ccdc149 | Pdzd3 | ENSMUSP00000062411 | ENSMUSP00000034618 | Coiled-coil domain-containing 149. | Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (By similarity). Stimulates SLC9A3 activity in the presence of elevated calcium ions (By similarity). | 0.668 |
Ccdc149 | Ppp2r5c | ENSMUSP00000062411 | ENSMUSP00000082053 | Coiled-coil domain-containing 149. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity). | 0.658 |
Ccdc149 | Slc36a1 | ENSMUSP00000062411 | ENSMUSP00000104500 | Coiled-coil domain-containing 149. | Proton-coupled amino acid transporter 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognizes their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid. | 0.514 |
Ccdc149 | Srgap2 | ENSMUSP00000062411 | ENSMUSP00000095195 | Coiled-coil domain-containing 149. | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.609 |
Ccdc149 | Srgap3 | ENSMUSP00000062411 | ENSMUSP00000085712 | Coiled-coil domain-containing 149. | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps CDC42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons (By similarity). | 0.545 |
Dlgap1 | Ccdc149 | ENSMUSP00000122896 | ENSMUSP00000062411 | Disks large-associated protein 1; Part of the postsynaptic scaffold in neuronal cells; Belongs to the SAPAP family. | Coiled-coil domain-containing 149. | 0.583 |
Dlgap1 | Myo10 | ENSMUSP00000122896 | ENSMUSP00000106087 | Disks large-associated protein 1; Part of the postsynaptic scaffold in neuronal cells; Belongs to the SAPAP family. | Unconventional myosin-X; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments (By similarity). Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippo [...] | 0.419 |
Dlgap1 | Srgap2 | ENSMUSP00000122896 | ENSMUSP00000095195 | Disks large-associated protein 1; Part of the postsynaptic scaffold in neuronal cells; Belongs to the SAPAP family. | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.443 |
Dlgap1 | Srgap3 | ENSMUSP00000122896 | ENSMUSP00000085712 | Disks large-associated protein 1; Part of the postsynaptic scaffold in neuronal cells; Belongs to the SAPAP family. | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps CDC42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons (By similarity). | 0.486 |
Iqca | Adgb | ENSMUSP00000108717 | ENSMUSP00000045452 | Dynein regulatory complex protein 11; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the AAA ATPase family. DRC11 subfamily. | Androglobin; Belongs to the peptidase C2 family. | 0.558 |
Iqca | Ccdc149 | ENSMUSP00000108717 | ENSMUSP00000062411 | Dynein regulatory complex protein 11; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the AAA ATPase family. DRC11 subfamily. | Coiled-coil domain-containing 149. | 0.514 |