STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Actrt1Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family. (376 aa)    
Predicted Functional Partners:
Zfy2
Zinc finger Y-chromosomal protein 2; Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).
   
 
 0.685
H2ab3
Histone H2A; Belongs to the histone H2A family.
   
 
 0.673
Btbd35f23
BTB domain-containing 35, family member 23.
   
  
 0.638
Btbd35f21
BTB domain-containing 35, family member 21.
   
  
 0.637
Btbd35f5
Germ cell-less protein-like 2; Possible function in spermatogenesis. Probable substrate- specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
   
  
 0.635
Slxl1
Slx-like 1.
   
  
 0.631
Rhox3h
Reproductive homeobox 3H.
   
 
 0.630
Capza3
F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid.
   
 
 0.625
Prr13
Proline-rich protein 13; Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis (By similarity).
   
 
 0.617
Slx
Sycp3-like X-linked.
      
 0.600
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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