node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aoc1 | Doxl1 | ENSMUSP00000124085 | ENSMUSP00000031837 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase. | 0.903 |
Aoc1 | Doxl2 | ENSMUSP00000124085 | ENSMUSP00000139012 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.903 |
Aoc1 | Hdc | ENSMUSP00000124085 | ENSMUSP00000028838 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. | 0.962 |
Aoc1 | Hnmt | ENSMUSP00000124085 | ENSMUSP00000062747 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Histamine N-methyltransferase; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. | 0.975 |
Aoc1 | Hrh1 | ENSMUSP00000124085 | ENSMUSP00000086383 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses. | 0.432 |
Aoc1 | Hrh2 | ENSMUSP00000124085 | ENSMUSP00000038170 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.442 |
Aoc1 | Hrh3 | ENSMUSP00000124085 | ENSMUSP00000049963 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Histamine H3 receptor; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist) (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.401 |
Aoc1 | Maoa | ENSMUSP00000124085 | ENSMUSP00000026013 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). | 0.951 |
Aoc1 | Maob | ENSMUSP00000124085 | ENSMUSP00000040550 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). | 0.957 |
Aoc1 | Svs1 | ENSMUSP00000124085 | ENSMUSP00000045221 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.904 |
Doxl1 | Aoc1 | ENSMUSP00000031837 | ENSMUSP00000124085 | Amine oxidase. | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | 0.903 |
Doxl1 | Doxl2 | ENSMUSP00000031837 | ENSMUSP00000139012 | Amine oxidase. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.902 |
Doxl1 | Hdc | ENSMUSP00000031837 | ENSMUSP00000028838 | Amine oxidase. | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. | 0.964 |
Doxl1 | Hnmt | ENSMUSP00000031837 | ENSMUSP00000062747 | Amine oxidase. | Histamine N-methyltransferase; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. | 0.975 |
Doxl1 | Hrh2 | ENSMUSP00000031837 | ENSMUSP00000038170 | Amine oxidase. | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.440 |
Doxl1 | Hrh3 | ENSMUSP00000031837 | ENSMUSP00000049963 | Amine oxidase. | Histamine H3 receptor; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist) (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.405 |
Doxl1 | Maoa | ENSMUSP00000031837 | ENSMUSP00000026013 | Amine oxidase. | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). | 0.954 |
Doxl1 | Maob | ENSMUSP00000031837 | ENSMUSP00000040550 | Amine oxidase. | Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). | 0.958 |
Doxl1 | Svs1 | ENSMUSP00000031837 | ENSMUSP00000045221 | Amine oxidase. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.911 |
Doxl2 | Aoc1 | ENSMUSP00000139012 | ENSMUSP00000124085 | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | 0.903 |