node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acaa1a | Acaa1b | ENSMUSP00000042351 | ENSMUSP00000010795 | 3-ketoacyl-CoA thiolase A, peroxisomal. | 3-ketoacyl-CoA thiolase B, peroxisomal. | 0.919 |
Acaa1a | Acadl | ENSMUSP00000042351 | ENSMUSP00000027153 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] | 0.975 |
Acaa1a | Acadm | ENSMUSP00000042351 | ENSMUSP00000072483 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). | 0.969 |
Acaa1a | Acox1 | ENSMUSP00000042351 | ENSMUSP00000063325 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.991 |
Acaa1a | Cpt2 | ENSMUSP00000042351 | ENSMUSP00000030345 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family. | 0.736 |
Acaa1a | Echs1 | ENSMUSP00000042351 | ENSMUSP00000026538 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity). | 0.863 |
Acaa1a | Ehhadh | ENSMUSP00000042351 | ENSMUSP00000023559 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.990 |
Acaa1a | Hadhb | ENSMUSP00000042351 | ENSMUSP00000110434 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] | 0.527 |
Acaa1a | Hsd17b4 | ENSMUSP00000042351 | ENSMUSP00000025385 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids (By similarity). | 0.980 |
Acaa1a | Scp2 | ENSMUSP00000042351 | ENSMUSP00000030340 | 3-ketoacyl-CoA thiolase A, peroxisomal. | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. | 0.970 |
Acaa1b | Acaa1a | ENSMUSP00000010795 | ENSMUSP00000042351 | 3-ketoacyl-CoA thiolase B, peroxisomal. | 3-ketoacyl-CoA thiolase A, peroxisomal. | 0.919 |
Acaa1b | Acadl | ENSMUSP00000010795 | ENSMUSP00000027153 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] | 0.975 |
Acaa1b | Acadm | ENSMUSP00000010795 | ENSMUSP00000072483 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). | 0.972 |
Acaa1b | Acox1 | ENSMUSP00000010795 | ENSMUSP00000063325 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity). | 0.987 |
Acaa1b | Cpt2 | ENSMUSP00000010795 | ENSMUSP00000030345 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family. | 0.738 |
Acaa1b | Echs1 | ENSMUSP00000010795 | ENSMUSP00000026538 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity). | 0.849 |
Acaa1b | Ehhadh | ENSMUSP00000010795 | ENSMUSP00000023559 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.991 |
Acaa1b | Hadhb | ENSMUSP00000010795 | ENSMUSP00000110434 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] | 0.512 |
Acaa1b | Hsd17b4 | ENSMUSP00000010795 | ENSMUSP00000025385 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids (By similarity). | 0.971 |
Acaa1b | Scp2 | ENSMUSP00000010795 | ENSMUSP00000030340 | 3-ketoacyl-CoA thiolase B, peroxisomal. | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. | 0.966 |