STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mtif3Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. (276 aa)    
Predicted Functional Partners:
Mtif2
Translation initiation factor IF-2, mitochondrial; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
   
 
 0.921
Ptcd3
Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation.
   
 
 0.843
Rbfa
Putative ribosome-binding factor A, mitochondrial.
   
 
 0.841
Dap3
28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death. Belongs to the mitochondrion-specific ribosomal protein mS29 family.
   
 
 0.764
Mrps35
28S ribosomal protein S35, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS35 family.
   
 
 0.758
Mrps31
28S ribosomal protein S31, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS31 family.
   
 
 0.756
Eif5b
Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.
   
 
 0.742
Oosp1
Oocyte-secreted protein 1; May be involved in cell differentiation. Belongs to the PLAC1 family.
      
 0.740
Mrps18b
28S ribosomal protein S18b, mitochondrial.
   
 
 0.725
Chchd1
Coiled-coil-helix-coiled-coil-helix domain-containing protein 1; Belongs to the mitochondrion-specific ribosomal protein mS37 family.
   
 
 0.705
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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