node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Capzb | Plekho2 | ENSMUSP00000030518 | ENSMUSP00000063677 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Isoform 3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. Plays a role in the regulation of cell morphology and cytoskeletal organization (By sim [...] | Pleckstrin homology domain-containing family O member 2. | 0.486 |
Fancg | Il10rb | ENSMUSP00000030165 | ENSMUSP00000023691 | Fanconi anemia group G protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (By similarity). | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | 0.435 |
Fancg | Plekho2 | ENSMUSP00000030165 | ENSMUSP00000063677 | Fanconi anemia group G protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (By similarity). | Pleckstrin homology domain-containing family O member 2. | 0.424 |
Gm21970 | Plekho2 | ENSMUSP00000123997 | ENSMUSP00000063677 | Predicted gene 21970. | Pleckstrin homology domain-containing family O member 2. | 0.420 |
Il10rb | Fancg | ENSMUSP00000023691 | ENSMUSP00000030165 | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | Fanconi anemia group G protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (By similarity). | 0.435 |
Il10rb | Plekho2 | ENSMUSP00000023691 | ENSMUSP00000063677 | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | Pleckstrin homology domain-containing family O member 2. | 0.556 |
Mgat4e | Plekho2 | ENSMUSP00000133717 | ENSMUSP00000063677 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E; Glycosyltransferase-like protein that may participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. | Pleckstrin homology domain-containing family O member 2. | 0.485 |
Plekho2 | Capzb | ENSMUSP00000063677 | ENSMUSP00000030518 | Pleckstrin homology domain-containing family O member 2. | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Isoform 3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. Plays a role in the regulation of cell morphology and cytoskeletal organization (By sim [...] | 0.486 |
Plekho2 | Fancg | ENSMUSP00000063677 | ENSMUSP00000030165 | Pleckstrin homology domain-containing family O member 2. | Fanconi anemia group G protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (By similarity). | 0.424 |
Plekho2 | Gm21970 | ENSMUSP00000063677 | ENSMUSP00000123997 | Pleckstrin homology domain-containing family O member 2. | Predicted gene 21970. | 0.420 |
Plekho2 | Il10rb | ENSMUSP00000063677 | ENSMUSP00000023691 | Pleckstrin homology domain-containing family O member 2. | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state (By similarity). | 0.556 |
Plekho2 | Mgat4e | ENSMUSP00000063677 | ENSMUSP00000133717 | Pleckstrin homology domain-containing family O member 2. | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E; Glycosyltransferase-like protein that may participate in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. | 0.485 |
Plekho2 | Themis2 | ENSMUSP00000063677 | ENSMUSP00000036945 | Pleckstrin homology domain-containing family O member 2. | Protein THEMIS2; May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Belongs to the themis family. | 0.441 |
Plekho2 | Tmc7 | ENSMUSP00000063677 | ENSMUSP00000046927 | Pleckstrin homology domain-containing family O member 2. | Transmembrane channel-like protein 7; Probable ion channel; Belongs to the TMC family. | 0.404 |
Themis2 | Plekho2 | ENSMUSP00000036945 | ENSMUSP00000063677 | Protein THEMIS2; May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Belongs to the themis family. | Pleckstrin homology domain-containing family O member 2. | 0.441 |
Tmc7 | Plekho2 | ENSMUSP00000046927 | ENSMUSP00000063677 | Transmembrane channel-like protein 7; Probable ion channel; Belongs to the TMC family. | Pleckstrin homology domain-containing family O member 2. | 0.404 |