node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agap3 | Krba1 | ENSMUSP00000024123 | ENSMUSP00000110219 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. | Protein KRBA1. | 0.409 |
Agap3 | Wdr86 | ENSMUSP00000024123 | ENSMUSP00000064785 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. | WD repeat domain 86. | 0.528 |
Agap3 | Zfp282 | ENSMUSP00000024123 | ENSMUSP00000053643 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. | Zinc finger protein 282. | 0.465 |
Cdc6 | Cul1 | ENSMUSP00000091469 | ENSMUSP00000031697 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] | 0.525 |
Cdc6 | Skp1a | ENSMUSP00000091469 | ENSMUSP00000104700 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.548 |
Cdc6 | Wdr86 | ENSMUSP00000091469 | ENSMUSP00000064785 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | WD repeat domain 86. | 0.552 |
Crygn | Krba1 | ENSMUSP00000035860 | ENSMUSP00000110219 | Gamma-crystallin N; Crystallins are the dominant structural components of the vertebrate eye lens (Probable). Plays also an important role for integrity and function of auditory nuclei. Belongs to the beta/gamma-crystallin family. | Protein KRBA1. | 0.429 |
Crygn | Wdr86 | ENSMUSP00000035860 | ENSMUSP00000064785 | Gamma-crystallin N; Crystallins are the dominant structural components of the vertebrate eye lens (Probable). Plays also an important role for integrity and function of auditory nuclei. Belongs to the beta/gamma-crystallin family. | WD repeat domain 86. | 0.628 |
Cul1 | Cdc6 | ENSMUSP00000031697 | ENSMUSP00000091469 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. | 0.525 |
Cul1 | Rbx1 | ENSMUSP00000031697 | ENSMUSP00000023036 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] | E3 ubiquitin-protein ligase RBX1, N-terminally processed; E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional spec [...] | 0.999 |
Cul1 | Skp1a | ENSMUSP00000031697 | ENSMUSP00000104700 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
Cul1 | Wdr86 | ENSMUSP00000031697 | ENSMUSP00000064785 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] | WD repeat domain 86. | 0.530 |
ETV3L | Wdr86 | ENSMUSP00000159067 | ENSMUSP00000064785 | ETS variant 3 like. | WD repeat domain 86. | 0.547 |
Galntl5 | Krba1 | ENSMUSP00000030778 | ENSMUSP00000110219 | Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. | Protein KRBA1. | 0.404 |
Galntl5 | Wdr86 | ENSMUSP00000030778 | ENSMUSP00000064785 | Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. | WD repeat domain 86. | 0.515 |
Galntl5 | Zfp282 | ENSMUSP00000030778 | ENSMUSP00000053643 | Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. | Zinc finger protein 282. | 0.432 |
Krba1 | Agap3 | ENSMUSP00000110219 | ENSMUSP00000024123 | Protein KRBA1. | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. | 0.409 |
Krba1 | Crygn | ENSMUSP00000110219 | ENSMUSP00000035860 | Protein KRBA1. | Gamma-crystallin N; Crystallins are the dominant structural components of the vertebrate eye lens (Probable). Plays also an important role for integrity and function of auditory nuclei. Belongs to the beta/gamma-crystallin family. | 0.429 |
Krba1 | Galntl5 | ENSMUSP00000110219 | ENSMUSP00000030778 | Protein KRBA1. | Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. | 0.404 |
Krba1 | Wdr86 | ENSMUSP00000110219 | ENSMUSP00000064785 | Protein KRBA1. | WD repeat domain 86. | 0.589 |