• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
Hbb-bh1 protein (mouse) - STRING interaction network
"Hbb-bh1" - Hemoglobin subunit beta-H1 in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Hbb-bh1Hemoglobin subunit beta-H1; This is an embryonic beta-type chain (147 aa)    
Predicted Functional Partners:
Hba-a1
Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family (142 aa)
     
0.935
Hba-x
Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin (142 aa)
     
0.915
Hbb-y
Hemoglobin subunit epsilon-Y2; Hemoglobin epsilon chain is a beta-type chain found in early embryos (147 aa)
     
 
0.912
Hbb-bt
Hemoglobin subunit beta-1; Involved in oxygen transport from the lung to the various peripheral tissues (147 aa)
     
0.771
Hba-a2
Hemoglobin alpha, adult chain 2 (142 aa)
     
 
0.749
Serpina10
Protein Z-dependent protease inhibitor; Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity); Belongs to the serpin family (448 aa)
           
  0.711
Klf1
Krueppel-like factor 1; Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation; Belongs to the krueppel C2H2-type zinc-finger protein family (376 aa)
     
 
  0.702
Gata1
Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5’-[AT]GATA[AG]-3’ within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (By similarity) (413 aa)
     
   
  0.659
Alas2
5-aminolevulinate synthase, erythroid-specific, mitochondrial; Aminolevulinic acid synthase 2, erythroid (587 aa)
     
   
  0.639
Bcl11a
B-cell lymphoma/leukemia 11A; Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (773 aa)
       
 
  0.588
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
Server load: low (16%) [HD]