node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gnrh1 | Gnrhr | ENSMUSP00000106724 | ENSMUSP00000031172 | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. | 0.999 |
Gnrh1 | Gpr101 | ENSMUSP00000106724 | ENSMUSP00000058183 | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.579 |
Gnrh1 | Gpr173 | ENSMUSP00000106724 | ENSMUSP00000065533 | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. | 0.431 |
Gnrh1 | Kiss1 | ENSMUSP00000106724 | ENSMUSP00000007433 | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | Metastasis-suppressor KiSS-1; Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation [...] | 0.956 |
Gnrh1 | Smim20 | ENSMUSP00000106724 | ENSMUSP00000121637 | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | Small integral membrane protein 20; [Small integral membrane protein 20]: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (By similarity). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (By similarity). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (By similarity). [Phoenixin-20]: Peptide involved in a broad spectrum of regulatory func [...] | 0.451 |
Gnrhr | Gnrh1 | ENSMUSP00000031172 | ENSMUSP00000106724 | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | 0.999 |
Gnrhr | Gpr173 | ENSMUSP00000031172 | ENSMUSP00000065533 | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. | 0.633 |
Gnrhr | Kiss1 | ENSMUSP00000031172 | ENSMUSP00000007433 | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. | Metastasis-suppressor KiSS-1; Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation [...] | 0.876 |
Gnrhr | Smim20 | ENSMUSP00000031172 | ENSMUSP00000121637 | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. | Small integral membrane protein 20; [Small integral membrane protein 20]: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (By similarity). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (By similarity). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (By similarity). [Phoenixin-20]: Peptide involved in a broad spectrum of regulatory func [...] | 0.512 |
Gpr101 | Gnrh1 | ENSMUSP00000058183 | ENSMUSP00000106724 | Probable G-protein coupled receptor 101; Orphan receptor. | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | 0.579 |
Gpr101 | Gpr173 | ENSMUSP00000058183 | ENSMUSP00000065533 | Probable G-protein coupled receptor 101; Orphan receptor. | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. | 0.410 |
Gpr142 | Gpr160 | ENSMUSP00000102194 | ENSMUSP00000103896 | Probable G-protein coupled receptor 142; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.478 |
Gpr142 | Gpr173 | ENSMUSP00000102194 | ENSMUSP00000065533 | Probable G-protein coupled receptor 142; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. | 0.401 |
Gpr160 | Gpr142 | ENSMUSP00000103896 | ENSMUSP00000102194 | Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 142; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.478 |
Gpr160 | Gpr173 | ENSMUSP00000103896 | ENSMUSP00000065533 | Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. | 0.501 |
Gpr173 | Gnrh1 | ENSMUSP00000065533 | ENSMUSP00000106724 | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. | Prolactin release-inhibiting factor 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | 0.431 |
Gpr173 | Gnrhr | ENSMUSP00000065533 | ENSMUSP00000031172 | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. | 0.633 |
Gpr173 | Gpr101 | ENSMUSP00000065533 | ENSMUSP00000058183 | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.410 |
Gpr173 | Gpr142 | ENSMUSP00000065533 | ENSMUSP00000102194 | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. | Probable G-protein coupled receptor 142; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.401 |
Gpr173 | Gpr160 | ENSMUSP00000065533 | ENSMUSP00000103896 | Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth. | Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.501 |