node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acbd3 | Pi4kb | ENSMUSP00000027780 | ENSMUSP00000102872 | Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (By similarity). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (By similarity). | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity); Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | 0.971 |
Acbd3 | Tbc1d22a | ENSMUSP00000027780 | ENSMUSP00000065721 | Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (By similarity). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (By similarity). | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | 0.711 |
Mon2 | Tbc1d22a | ENSMUSP00000073462 | ENSMUSP00000065721 | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family. | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | 0.524 |
Mospd3 | Tbc1d22a | ENSMUSP00000040828 | ENSMUSP00000065721 | Motile sperm domain-containing protein 3. | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | 0.564 |
Pi4kb | Acbd3 | ENSMUSP00000102872 | ENSMUSP00000027780 | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity); Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (By similarity). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (By similarity). | 0.971 |
Pi4kb | Tbc1d22a | ENSMUSP00000102872 | ENSMUSP00000065721 | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity); Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | 0.530 |
Tbc1d10c | Tbc1d19 | ENSMUSP00000158437 | ENSMUSP00000040585 | Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity). | TBC1 domain family, member 19. | 0.680 |
Tbc1d10c | Tbc1d20 | ENSMUSP00000158437 | ENSMUSP00000028963 | Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity). | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. | 0.551 |
Tbc1d10c | Tbc1d21 | ENSMUSP00000158437 | ENSMUSP00000037525 | Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity). | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | 0.728 |
Tbc1d10c | Tbc1d22a | ENSMUSP00000158437 | ENSMUSP00000065721 | Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity). | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | 0.499 |
Tbc1d10c | Tbc1d5 | ENSMUSP00000158437 | ENSMUSP00000024717 | Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity). | TBC1 domain family member 5; May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming ves [...] | 0.546 |
Tbc1d19 | Tbc1d10c | ENSMUSP00000040585 | ENSMUSP00000158437 | TBC1 domain family, member 19. | Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity). | 0.680 |
Tbc1d19 | Tbc1d20 | ENSMUSP00000040585 | ENSMUSP00000028963 | TBC1 domain family, member 19. | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. | 0.549 |
Tbc1d19 | Tbc1d21 | ENSMUSP00000040585 | ENSMUSP00000037525 | TBC1 domain family, member 19. | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | 0.725 |
Tbc1d19 | Tbc1d22a | ENSMUSP00000040585 | ENSMUSP00000065721 | TBC1 domain family, member 19. | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | 0.577 |
Tbc1d19 | Tbc1d5 | ENSMUSP00000040585 | ENSMUSP00000024717 | TBC1 domain family, member 19. | TBC1 domain family member 5; May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming ves [...] | 0.476 |
Tbc1d20 | Tbc1d10c | ENSMUSP00000028963 | ENSMUSP00000158437 | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. | Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity). | 0.551 |
Tbc1d20 | Tbc1d19 | ENSMUSP00000028963 | ENSMUSP00000040585 | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. | TBC1 domain family, member 19. | 0.549 |
Tbc1d20 | Tbc1d21 | ENSMUSP00000028963 | ENSMUSP00000037525 | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | 0.627 |
Tbc1d20 | Tbc1d22a | ENSMUSP00000028963 | ENSMUSP00000065721 | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | 0.608 |