node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bpifa3 | Bpifb6 | ENSMUSP00000028984 | ENSMUSP00000086347 | BPI fold-containing family A member 3. | BPI fold-containing family B member 6. | 0.633 |
Bpifa3 | Cib4 | ENSMUSP00000028984 | ENSMUSP00000066222 | BPI fold-containing family A member 3. | Calcium and integrin-binding family member 4. | 0.527 |
Bpifb6 | Bpifa3 | ENSMUSP00000086347 | ENSMUSP00000028984 | BPI fold-containing family B member 6. | BPI fold-containing family A member 3. | 0.633 |
Bpifb6 | Cib4 | ENSMUSP00000086347 | ENSMUSP00000066222 | BPI fold-containing family B member 6. | Calcium and integrin-binding family member 4. | 0.556 |
Cib4 | Bpifa3 | ENSMUSP00000066222 | ENSMUSP00000028984 | Calcium and integrin-binding family member 4. | BPI fold-containing family A member 3. | 0.527 |
Cib4 | Bpifb6 | ENSMUSP00000066222 | ENSMUSP00000086347 | Calcium and integrin-binding family member 4. | BPI fold-containing family B member 6. | 0.556 |
Cib4 | Klhdc7b | ENSMUSP00000066222 | ENSMUSP00000130884 | Calcium and integrin-binding family member 4. | Kelch domain-containing 7B. | 0.599 |
Cib4 | Lrguk | ENSMUSP00000066222 | ENSMUSP00000065146 | Calcium and integrin-binding family member 4. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.588 |
Cib4 | Ppp3cc | ENSMUSP00000066222 | ENSMUSP00000077532 | Calcium and integrin-binding family member 4. | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. | 0.552 |
Cib4 | Spef2 | ENSMUSP00000066222 | ENSMUSP00000035762 | Calcium and integrin-binding family member 4. | Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. | 0.609 |
Cib4 | Ssmem1 | ENSMUSP00000066222 | ENSMUSP00000031798 | Calcium and integrin-binding family member 4. | Serine-rich single-pass membrane protein 1. | 0.580 |
Cib4 | Tmc2 | ENSMUSP00000066222 | ENSMUSP00000077139 | Calcium and integrin-binding family member 4. | Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity). | 0.592 |
Cib4 | Tssk4 | ENSMUSP00000066222 | ENSMUSP00000007735 | Calcium and integrin-binding family member 4. | Testis-specific serine/threonine-protein kinase 4; [Isoform 1]: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'. [Isoform 3]: Catalytically inactive. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.591 |
Cib4 | Whrn | ENSMUSP00000066222 | ENSMUSP00000081557 | Calcium and integrin-binding family member 4. | Whirlin; Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. | 0.544 |
Klhdc7b | Cib4 | ENSMUSP00000130884 | ENSMUSP00000066222 | Kelch domain-containing 7B. | Calcium and integrin-binding family member 4. | 0.599 |
Lrguk | Cib4 | ENSMUSP00000065146 | ENSMUSP00000066222 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Calcium and integrin-binding family member 4. | 0.588 |
Lrguk | Spef2 | ENSMUSP00000065146 | ENSMUSP00000035762 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. | 0.754 |
Lrguk | Ssmem1 | ENSMUSP00000065146 | ENSMUSP00000031798 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Serine-rich single-pass membrane protein 1. | 0.695 |
Lrguk | Tssk4 | ENSMUSP00000065146 | ENSMUSP00000007735 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Testis-specific serine/threonine-protein kinase 4; [Isoform 1]: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'. [Isoform 3]: Catalytically inactive. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.626 |
Ppp3cc | Cib4 | ENSMUSP00000077532 | ENSMUSP00000066222 | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. | Calcium and integrin-binding family member 4. | 0.552 |