node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arrdc2 | Zcchc24 | ENSMUSP00000002989 | ENSMUSP00000068677 | Arrestin domain-containing protein 2. | Zinc finger CCHC domain-containing protein 24. | 0.495 |
Ccdc150 | Zcchc24 | ENSMUSP00000027128 | ENSMUSP00000068677 | Coiled-coil domain-containing protein 150. | Zinc finger CCHC domain-containing protein 24. | 0.456 |
Cstf3 | Zcchc24 | ENSMUSP00000028599 | ENSMUSP00000068677 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | Zinc finger CCHC domain-containing protein 24. | 0.473 |
Esrp1 | Grhl1 | ENSMUSP00000103947 | ENSMUSP00000082689 | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and exp [...] | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3 no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | 0.564 |
Esrp1 | Rbm47 | ENSMUSP00000103947 | ENSMUSP00000144122 | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and exp [...] | RNA-binding protein 47; Belongs to the RRM RBM47 family. | 0.552 |
Esrp1 | Zcchc24 | ENSMUSP00000103947 | ENSMUSP00000068677 | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and exp [...] | Zinc finger CCHC domain-containing protein 24. | 0.467 |
Fam126a | Tmem109 | ENSMUSP00000030849 | ENSMUSP00000039529 | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway. | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity). | 0.459 |
Fam126a | Zcchc24 | ENSMUSP00000030849 | ENSMUSP00000068677 | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway. | Zinc finger CCHC domain-containing protein 24. | 0.459 |
Grhl1 | Esrp1 | ENSMUSP00000082689 | ENSMUSP00000103947 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3 no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and exp [...] | 0.564 |
Grhl1 | Zcchc24 | ENSMUSP00000082689 | ENSMUSP00000068677 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3 no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily. | Zinc finger CCHC domain-containing protein 24. | 0.464 |
Mmd2 | Zcchc24 | ENSMUSP00000039357 | ENSMUSP00000068677 | Monocyte to macrophage differentiation factor 2; Belongs to the ADIPOR family. | Zinc finger CCHC domain-containing protein 24. | 0.435 |
Rbm47 | Esrp1 | ENSMUSP00000144122 | ENSMUSP00000103947 | RNA-binding protein 47; Belongs to the RRM RBM47 family. | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and exp [...] | 0.552 |
Rbm47 | Zcchc24 | ENSMUSP00000144122 | ENSMUSP00000068677 | RNA-binding protein 47; Belongs to the RRM RBM47 family. | Zinc finger CCHC domain-containing protein 24. | 0.635 |
Sh3rf3 | Zcchc24 | ENSMUSP00000120938 | ENSMUSP00000068677 | E3 ubiquitin-protein ligase SH3RF3; Has E3 ubiquitin-protein ligase activity. | Zinc finger CCHC domain-containing protein 24. | 0.506 |
Tmem109 | Fam126a | ENSMUSP00000039529 | ENSMUSP00000030849 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity). | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway. | 0.459 |
Tmem109 | Zcchc24 | ENSMUSP00000039529 | ENSMUSP00000068677 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity). | Zinc finger CCHC domain-containing protein 24. | 0.515 |
Zcchc24 | Arrdc2 | ENSMUSP00000068677 | ENSMUSP00000002989 | Zinc finger CCHC domain-containing protein 24. | Arrestin domain-containing protein 2. | 0.495 |
Zcchc24 | Ccdc150 | ENSMUSP00000068677 | ENSMUSP00000027128 | Zinc finger CCHC domain-containing protein 24. | Coiled-coil domain-containing protein 150. | 0.456 |
Zcchc24 | Cstf3 | ENSMUSP00000068677 | ENSMUSP00000028599 | Zinc finger CCHC domain-containing protein 24. | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. | 0.473 |
Zcchc24 | Esrp1 | ENSMUSP00000068677 | ENSMUSP00000103947 | Zinc finger CCHC domain-containing protein 24. | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and exp [...] | 0.467 |