node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgap25 | Pld5 | ENSMUSP00000109267 | ENSMUSP00000069326 | Rho GTPase-activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Inactive phospholipase D5; Belongs to the phospholipase D family. | 0.491 |
Far2 | Npsr1 | ENSMUSP00000032443 | ENSMUSP00000056432 | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). | Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. | 0.439 |
Far2 | Pld5 | ENSMUSP00000032443 | ENSMUSP00000069326 | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). | Inactive phospholipase D5; Belongs to the phospholipase D family. | 0.489 |
Lhfpl4 | Pld5 | ENSMUSP00000124470 | ENSMUSP00000069326 | LHFPL tetraspan subfamily member 4 protein; Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma- aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. | Inactive phospholipase D5; Belongs to the phospholipase D family. | 0.453 |
Npsr1 | Far2 | ENSMUSP00000056432 | ENSMUSP00000032443 | Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). | 0.439 |
Npsr1 | Pld5 | ENSMUSP00000056432 | ENSMUSP00000069326 | Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. | Inactive phospholipase D5; Belongs to the phospholipase D family. | 0.470 |
Npsr1 | Rpl10a | ENSMUSP00000056432 | ENSMUSP00000048469 | Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. | 60S ribosomal protein L10a; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL1 family. | 0.840 |
Pld1 | Pld2 | ENSMUSP00000113810 | ENSMUSP00000104197 | Phospholipase D1; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic. | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis. | 0.909 |
Pld1 | Pld5 | ENSMUSP00000113810 | ENSMUSP00000069326 | Phospholipase D1; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic. | Inactive phospholipase D5; Belongs to the phospholipase D family. | 0.446 |
Pld1 | Pld6 | ENSMUSP00000113810 | ENSMUSP00000115503 | Phospholipase D1; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.440 |
Pld2 | Pld1 | ENSMUSP00000104197 | ENSMUSP00000113810 | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis. | Phospholipase D1; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic. | 0.909 |
Pld2 | Pld5 | ENSMUSP00000104197 | ENSMUSP00000069326 | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis. | Inactive phospholipase D5; Belongs to the phospholipase D family. | 0.665 |
Pld2 | Pld6 | ENSMUSP00000104197 | ENSMUSP00000115503 | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.621 |
Pld5 | Arhgap25 | ENSMUSP00000069326 | ENSMUSP00000109267 | Inactive phospholipase D5; Belongs to the phospholipase D family. | Rho GTPase-activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.491 |
Pld5 | Far2 | ENSMUSP00000069326 | ENSMUSP00000032443 | Inactive phospholipase D5; Belongs to the phospholipase D family. | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). | 0.489 |
Pld5 | Lhfpl4 | ENSMUSP00000069326 | ENSMUSP00000124470 | Inactive phospholipase D5; Belongs to the phospholipase D family. | LHFPL tetraspan subfamily member 4 protein; Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma- aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs. | 0.453 |
Pld5 | Npsr1 | ENSMUSP00000069326 | ENSMUSP00000056432 | Inactive phospholipase D5; Belongs to the phospholipase D family. | Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases. | 0.470 |
Pld5 | Pld1 | ENSMUSP00000069326 | ENSMUSP00000113810 | Inactive phospholipase D5; Belongs to the phospholipase D family. | Phospholipase D1; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic. | 0.446 |
Pld5 | Pld2 | ENSMUSP00000069326 | ENSMUSP00000104197 | Inactive phospholipase D5; Belongs to the phospholipase D family. | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis. | 0.665 |
Pld5 | Pld6 | ENSMUSP00000069326 | ENSMUSP00000115503 | Inactive phospholipase D5; Belongs to the phospholipase D family. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA- mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface. Although it cannot be excluded that it can act as [...] | 0.733 |