node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Casc1 | Ccdc114 | ENSMUSP00000062279 | ENSMUSP00000042772 | Protein CASC1; Belongs to the CASC1 family. | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | 0.750 |
Casc1 | Dnah2 | ENSMUSP00000062279 | ENSMUSP00000104299 | Protein CASC1; Belongs to the CASC1 family. | Dynein heavy chain 2, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family. | 0.925 |
Casc1 | Dnah5 | ENSMUSP00000062279 | ENSMUSP00000069751 | Protein CASC1; Belongs to the CASC1 family. | Dynein heavy chain 5, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Belongs to the dynein heavy chain family. | 0.922 |
Casc1 | Dnah9 | ENSMUSP00000062279 | ENSMUSP00000079494 | Protein CASC1; Belongs to the CASC1 family. | Dynein, axonemal, heavy chain 9. | 0.920 |
Casc1 | Dnaic1 | ENSMUSP00000062279 | ENSMUSP00000100028 | Protein CASC1; Belongs to the CASC1 family. | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia. | 0.790 |
Casc1 | Dnaic2 | ENSMUSP00000062279 | ENSMUSP00000065787 | Protein CASC1; Belongs to the CASC1 family. | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia. | 0.769 |
Casc1 | Dnal1 | ENSMUSP00000062279 | ENSMUSP00000121038 | Protein CASC1; Belongs to the CASC1 family. | Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-rig [...] | 0.767 |
Casc1 | Dync1i2 | ENSMUSP00000062279 | ENSMUSP00000107768 | Protein CASC1; Belongs to the CASC1 family. | Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). | 0.900 |
Casc1 | Nme8 | ENSMUSP00000062279 | ENSMUSP00000089358 | Protein CASC1; Belongs to the CASC1 family. | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (By similarity). | 0.720 |
Casc1 | Wdr63 | ENSMUSP00000062279 | ENSMUSP00000124475 | Protein CASC1; Belongs to the CASC1 family. | WD repeat domain 63. | 0.946 |
Ccdc114 | Casc1 | ENSMUSP00000042772 | ENSMUSP00000062279 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Protein CASC1; Belongs to the CASC1 family. | 0.750 |
Ccdc114 | Dnah2 | ENSMUSP00000042772 | ENSMUSP00000104299 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein heavy chain 2, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family. | 0.829 |
Ccdc114 | Dnah5 | ENSMUSP00000042772 | ENSMUSP00000069751 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein heavy chain 5, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Belongs to the dynein heavy chain family. | 0.961 |
Ccdc114 | Dnah9 | ENSMUSP00000042772 | ENSMUSP00000079494 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein, axonemal, heavy chain 9. | 0.875 |
Ccdc114 | Dnaic1 | ENSMUSP00000042772 | ENSMUSP00000100028 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia. | 0.954 |
Ccdc114 | Dnaic2 | ENSMUSP00000042772 | ENSMUSP00000065787 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia. | 0.937 |
Ccdc114 | Dnal1 | ENSMUSP00000042772 | ENSMUSP00000121038 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-rig [...] | 0.831 |
Ccdc114 | Dync1i2 | ENSMUSP00000042772 | ENSMUSP00000107768 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). | 0.769 |
Ccdc114 | Nme8 | ENSMUSP00000042772 | ENSMUSP00000089358 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (By similarity). | 0.946 |
Ccdc114 | Wdr63 | ENSMUSP00000042772 | ENSMUSP00000124475 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family. | WD repeat domain 63. | 0.839 |