STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ppp1r36Protein phosphatase 1 regulatory subunit 36; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. (411 aa)    
Predicted Functional Partners:
Plekhg3
Pleckstrin homology domain-containing family G member 3.
      
 0.700
Serpine3
Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Belongs to the serpin family.
      
 0.675
Wdr93
WD repeat-containing protein 93.
   
  
 0.613
Dnajc24
DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2).
   
  
 0.461
Mageb1
Melanoma antigen, family B, 1.
      
 0.457
Hspbap1
HSPB1-associated protein 1; May play a role in cellular stress response.
      
 0.451
Ddhd1
Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity (By similarity). Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). Belongs to the PA-PLA1 family.
      
 0.448
Gxylt2
Glucoside xylosyltransferase 2; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
   
  
 0.446
Ica1l
Islet cell autoantigen 1-like protein.
      
 0.440
Epg5
Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located.
      
 0.415
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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