node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
1700007K13Rik | Dand5 | ENSMUSP00000083557 | ENSMUSP00000070057 | UPF0691 protein C9orf116 homolog. | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | 0.554 |
Cers1 | Dand5 | ENSMUSP00000128325 | ENSMUSP00000070057 | Embryonic growth/differentiation factor 1; May mediate cell differentiation events during embryonic development. | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | 0.526 |
Cers1 | Lefty1 | ENSMUSP00000128325 | ENSMUSP00000041427 | Embryonic growth/differentiation factor 1; May mediate cell differentiation events during embryonic development. | Left-right determination factor 1; Required for left-right axis determination as a regulator of LEFTY2 and NODAL; Belongs to the TGF-beta family. | 0.567 |
Cers1 | Lefty2 | ENSMUSP00000128325 | ENSMUSP00000082952 | Embryonic growth/differentiation factor 1; May mediate cell differentiation events during embryonic development. | Left-right determination factor 2; Required for left-right asymmetry determination of organ systems in mammals; Belongs to the TGF-beta family. | 0.539 |
Cers1 | Nodal | ENSMUSP00000128325 | ENSMUSP00000039653 | Embryonic growth/differentiation factor 1; May mediate cell differentiation events during embryonic development. | Nodal; Essential for mesoderm formation and axial patterning during embryonic development; Belongs to the TGF-beta family. | 0.919 |
Cers1 | Pitx2 | ENSMUSP00000128325 | ENSMUSP00000047359 | Embryonic growth/differentiation factor 1; May mediate cell differentiation events during embryonic development. | Pituitary homeobox 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform Ptx2c is involved in left-right asymmetry the developing embryo. | 0.428 |
Dand5 | 1700007K13Rik | ENSMUSP00000070057 | ENSMUSP00000083557 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | UPF0691 protein C9orf116 homolog. | 0.554 |
Dand5 | Cers1 | ENSMUSP00000070057 | ENSMUSP00000128325 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | Embryonic growth/differentiation factor 1; May mediate cell differentiation events during embryonic development. | 0.526 |
Dand5 | Galnt11 | ENSMUSP00000070057 | ENSMUSP00000036240 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | Polypeptide N-acetylgalactosaminyltransferase 11; Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O- glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme a [...] | 0.554 |
Dand5 | Gdf1 | ENSMUSP00000070057 | ENSMUSP00000146749 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | Growth differentiation factor 1. | 0.624 |
Dand5 | Gm17018 | ENSMUSP00000070057 | ENSMUSP00000045683 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | Protein DPCD; May play a role in the formation or function of ciliated cells; Belongs to the DPCD family. | 0.481 |
Dand5 | Lefty1 | ENSMUSP00000070057 | ENSMUSP00000041427 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | Left-right determination factor 1; Required for left-right axis determination as a regulator of LEFTY2 and NODAL; Belongs to the TGF-beta family. | 0.655 |
Dand5 | Lefty2 | ENSMUSP00000070057 | ENSMUSP00000082952 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | Left-right determination factor 2; Required for left-right asymmetry determination of organ systems in mammals; Belongs to the TGF-beta family. | 0.608 |
Dand5 | Nodal | ENSMUSP00000070057 | ENSMUSP00000039653 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | Nodal; Essential for mesoderm formation and axial patterning during embryonic development; Belongs to the TGF-beta family. | 0.592 |
Dand5 | Pitx2 | ENSMUSP00000070057 | ENSMUSP00000047359 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | Pituitary homeobox 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform Ptx2c is involved in left-right asymmetry the developing embryo. | 0.665 |
Dand5 | Pkd1l1 | ENSMUSP00000070057 | ENSMUSP00000120803 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | Polycystic kidney disease protein 1-like 1; Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. | 0.607 |
Galnt11 | Dand5 | ENSMUSP00000036240 | ENSMUSP00000070057 | Polypeptide N-acetylgalactosaminyltransferase 11; Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O- glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme a [...] | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | 0.554 |
Gdf1 | Dand5 | ENSMUSP00000146749 | ENSMUSP00000070057 | Growth differentiation factor 1. | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, and tissue growth and differentiation. Belongs to the DAN family. | 0.624 |
Gdf1 | Lefty1 | ENSMUSP00000146749 | ENSMUSP00000041427 | Growth differentiation factor 1. | Left-right determination factor 1; Required for left-right axis determination as a regulator of LEFTY2 and NODAL; Belongs to the TGF-beta family. | 0.648 |
Gdf1 | Lefty2 | ENSMUSP00000146749 | ENSMUSP00000082952 | Growth differentiation factor 1. | Left-right determination factor 2; Required for left-right asymmetry determination of organ systems in mammals; Belongs to the TGF-beta family. | 0.619 |