node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acvrl1 | Tmem184b | ENSMUSP00000000542 | ENSMUSP00000074518 | Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway; Belongs to the TMEM184 family. | 0.443 |
Acvrl1 | Zfp46 | ENSMUSP00000000542 | ENSMUSP00000070216 | Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. | Zinc finger protein 436; May be involved in transcriptional regulation. | 0.409 |
Adamtsl5 | Dok4 | ENSMUSP00000093097 | ENSMUSP00000043554 | ADAMTS-like 5. | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity). | 0.612 |
Adamtsl5 | Pkp4 | ENSMUSP00000093097 | ENSMUSP00000099815 | ADAMTS-like 5. | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). Belongs to the beta-catenin family. | 0.529 |
Adamtsl5 | Tmem184b | ENSMUSP00000093097 | ENSMUSP00000074518 | ADAMTS-like 5. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway; Belongs to the TMEM184 family. | 0.657 |
Adamtsl5 | Zfp46 | ENSMUSP00000093097 | ENSMUSP00000070216 | ADAMTS-like 5. | Zinc finger protein 436; May be involved in transcriptional regulation. | 0.622 |
Cmklr1 | Tmem184b | ENSMUSP00000036316 | ENSMUSP00000074518 | Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte meta [...] | Transmembrane protein 184B; May activate the MAP kinase signaling pathway; Belongs to the TMEM184 family. | 0.427 |
Cmklr1 | Zfp46 | ENSMUSP00000036316 | ENSMUSP00000070216 | Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte meta [...] | Zinc finger protein 436; May be involved in transcriptional regulation. | 0.435 |
D10Wsu102e | Zfp46 | ENSMUSP00000020488 | ENSMUSP00000070216 | Uncharacterized protein C12orf45 homolog. | Zinc finger protein 436; May be involved in transcriptional regulation. | 0.426 |
Dok4 | Adamtsl5 | ENSMUSP00000043554 | ENSMUSP00000093097 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity). | ADAMTS-like 5. | 0.612 |
Dok4 | Pkp4 | ENSMUSP00000043554 | ENSMUSP00000099815 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity). | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). Belongs to the beta-catenin family. | 0.514 |
Dok4 | Tmem184b | ENSMUSP00000043554 | ENSMUSP00000074518 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity). | Transmembrane protein 184B; May activate the MAP kinase signaling pathway; Belongs to the TMEM184 family. | 0.688 |
Dok4 | Zfp46 | ENSMUSP00000043554 | ENSMUSP00000070216 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity). | Zinc finger protein 436; May be involved in transcriptional regulation. | 0.627 |
Pkp4 | Adamtsl5 | ENSMUSP00000099815 | ENSMUSP00000093097 | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). Belongs to the beta-catenin family. | ADAMTS-like 5. | 0.529 |
Pkp4 | Dok4 | ENSMUSP00000099815 | ENSMUSP00000043554 | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). Belongs to the beta-catenin family. | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity). | 0.514 |
Pkp4 | Tmem184b | ENSMUSP00000099815 | ENSMUSP00000074518 | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). Belongs to the beta-catenin family. | Transmembrane protein 184B; May activate the MAP kinase signaling pathway; Belongs to the TMEM184 family. | 0.559 |
Pkp4 | Zfp46 | ENSMUSP00000099815 | ENSMUSP00000070216 | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). Belongs to the beta-catenin family. | Zinc finger protein 436; May be involved in transcriptional regulation. | 0.578 |
Tmem184b | Acvrl1 | ENSMUSP00000074518 | ENSMUSP00000000542 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway; Belongs to the TMEM184 family. | Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. | 0.443 |
Tmem184b | Adamtsl5 | ENSMUSP00000074518 | ENSMUSP00000093097 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway; Belongs to the TMEM184 family. | ADAMTS-like 5. | 0.657 |
Tmem184b | Cmklr1 | ENSMUSP00000074518 | ENSMUSP00000036316 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway; Belongs to the TMEM184 family. | Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B (By similarity). Positively regulates adipogenesis and adipocyte meta [...] | 0.427 |