STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sh2d4aSH2 domain-containing protein 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation (By similarity). May play a role in T-cell development and function. (421 aa)    
Predicted Functional Partners:
Ppp1cb
Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...]
    
 
 0.710
Ccdc15
Coiled-coil domain-containing protein 15.
      
 0.648
H2ab2
Histone H2A; Belongs to the histone H2A family.
      
 0.552
Ppp1r7
Protein phosphatase 1 regulatory subunit 7; Regulatory subunit of protein phosphatase 1.
    
 
 0.524
Mycbpap
MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).
      
 0.523
Mthfsd
Methenyltetrahydrofolate synthase domain-containing protein.
   
  
 0.523
Ccdc25
Coiled-coil domain-containing protein 25; Belongs to the CCDC25 family.
      
 0.499
Scml2
Scm polycomb group protein-like 2.
      
 0.479
Plpbp
Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6.
      
 0.462
Spatc1
Speriolin; Belongs to the speriolin family.
      
 0.449
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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