node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAdacl4fm3 | Fam136a | ENSMUSP00000045343 | ENSMUSP00000071426 | AADACL4 family member 3. | Protein FAM136A; Belongs to the FAM136 family. | 0.489 |
Dnajc27 | Fam136a | ENSMUSP00000020986 | ENSMUSP00000071426 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family. | Protein FAM136A; Belongs to the FAM136 family. | 0.461 |
Dnajc27 | Ranbp6 | ENSMUSP00000020986 | ENSMUSP00000100503 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family. | Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor; Belongs to the importin beta family. | 0.460 |
Dtna | Fam136a | ENSMUSP00000111498 | ENSMUSP00000071426 | Dystrobrevin alpha; Involved in synapse maturation and required for normal muscle function. | Protein FAM136A; Belongs to the FAM136 family. | 0.731 |
Eny2 | Fam136a | ENSMUSP00000052905 | ENSMUSP00000071426 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | Protein FAM136A; Belongs to the FAM136 family. | 0.477 |
Fam136a | AAdacl4fm3 | ENSMUSP00000071426 | ENSMUSP00000045343 | Protein FAM136A; Belongs to the FAM136 family. | AADACL4 family member 3. | 0.489 |
Fam136a | Dnajc27 | ENSMUSP00000071426 | ENSMUSP00000020986 | Protein FAM136A; Belongs to the FAM136 family. | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family. | 0.461 |
Fam136a | Dtna | ENSMUSP00000071426 | ENSMUSP00000111498 | Protein FAM136A; Belongs to the FAM136 family. | Dystrobrevin alpha; Involved in synapse maturation and required for normal muscle function. | 0.731 |
Fam136a | Eny2 | ENSMUSP00000071426 | ENSMUSP00000052905 | Protein FAM136A; Belongs to the FAM136 family. | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] | 0.477 |
Fam136a | Mrps21 | ENSMUSP00000071426 | ENSMUSP00000066990 | Protein FAM136A; Belongs to the FAM136 family. | 28S ribosomal protein S21, mitochondrial; Belongs to the bacterial ribosomal protein bS21 family. | 0.492 |
Fam136a | Naa38 | ENSMUSP00000071426 | ENSMUSP00000123155 | Protein FAM136A; Belongs to the FAM136 family. | N-alpha-acetyltransferase 38, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues; Belongs to the snRNP Sm proteins family. | 0.537 |
Fam136a | Prkcb | ENSMUSP00000071426 | ENSMUSP00000070019 | Protein FAM136A; Belongs to the FAM136 family. | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] | 0.489 |
Fam136a | Ranbp6 | ENSMUSP00000071426 | ENSMUSP00000100503 | Protein FAM136A; Belongs to the FAM136 family. | Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor; Belongs to the importin beta family. | 0.527 |
Fam136a | Sema3d | ENSMUSP00000071426 | ENSMUSP00000030868 | Protein FAM136A; Belongs to the FAM136 family. | Semaphorin-3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity). | 0.640 |
Fam136a | Wdr55 | ENSMUSP00000071426 | ENSMUSP00000039010 | Protein FAM136A; Belongs to the FAM136 family. | WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. | 0.488 |
Mrps21 | Fam136a | ENSMUSP00000066990 | ENSMUSP00000071426 | 28S ribosomal protein S21, mitochondrial; Belongs to the bacterial ribosomal protein bS21 family. | Protein FAM136A; Belongs to the FAM136 family. | 0.492 |
Naa38 | Fam136a | ENSMUSP00000123155 | ENSMUSP00000071426 | N-alpha-acetyltransferase 38, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues; Belongs to the snRNP Sm proteins family. | Protein FAM136A; Belongs to the FAM136 family. | 0.537 |
Prkcb | Fam136a | ENSMUSP00000070019 | ENSMUSP00000071426 | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] | Protein FAM136A; Belongs to the FAM136 family. | 0.489 |
Ranbp6 | Dnajc27 | ENSMUSP00000100503 | ENSMUSP00000020986 | Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor; Belongs to the importin beta family. | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family. | 0.460 |
Ranbp6 | Fam136a | ENSMUSP00000100503 | ENSMUSP00000071426 | Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor; Belongs to the importin beta family. | Protein FAM136A; Belongs to the FAM136 family. | 0.527 |