node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fras1 | Frem1 | ENSMUSP00000043250 | ENSMUSP00000071627 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | 0.987 |
Fras1 | Frem2 | ENSMUSP00000043250 | ENSMUSP00000088670 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs ; Belongs to the FRAS1 family. | 0.984 |
Fras1 | Grip1 | ENSMUSP00000043250 | ENSMUSP00000123234 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (By similarity). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | 0.675 |
Fras1 | Itga8 | ENSMUSP00000043250 | ENSMUSP00000028106 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.941 |
Fras1 | Itgb1 | ENSMUSP00000043250 | ENSMUSP00000087457 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.908 |
Fras1 | Vwa2 | ENSMUSP00000043250 | ENSMUSP00000026068 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Von Willebrand factor A domain-containing protein 2. | 0.459 |
Frem1 | Fras1 | ENSMUSP00000071627 | ENSMUSP00000043250 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | 0.987 |
Frem1 | Frem2 | ENSMUSP00000071627 | ENSMUSP00000088670 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs ; Belongs to the FRAS1 family. | 0.990 |
Frem1 | Grip1 | ENSMUSP00000071627 | ENSMUSP00000123234 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (By similarity). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | 0.525 |
Frem1 | Igfbp7 | ENSMUSP00000071627 | ENSMUSP00000128318 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Insulin-like growth factor-binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity). | 0.514 |
Frem1 | Igfbpl1 | ENSMUSP00000071627 | ENSMUSP00000036974 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity). | 0.514 |
Frem1 | Itga8 | ENSMUSP00000071627 | ENSMUSP00000028106 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.940 |
Frem1 | Itgb1 | ENSMUSP00000071627 | ENSMUSP00000087457 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.907 |
Frem1 | Npnt | ENSMUSP00000071627 | ENSMUSP00000091505 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Nephronectin; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins. | 0.636 |
Frem1 | Tmem246 | ENSMUSP00000071627 | ENSMUSP00000040885 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Transmembrane protein 246. | 0.518 |
Frem1 | Vwa2 | ENSMUSP00000071627 | ENSMUSP00000026068 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Von Willebrand factor A domain-containing protein 2. | 0.595 |
Frem2 | Fras1 | ENSMUSP00000088670 | ENSMUSP00000043250 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs ; Belongs to the FRAS1 family. | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | 0.984 |
Frem2 | Frem1 | ENSMUSP00000088670 | ENSMUSP00000071627 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs ; Belongs to the FRAS1 family. | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | 0.990 |
Frem2 | Grip1 | ENSMUSP00000088670 | ENSMUSP00000123234 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs ; Belongs to the FRAS1 family. | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (By similarity). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | 0.719 |
Frem2 | Itga8 | ENSMUSP00000088670 | ENSMUSP00000028106 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs ; Belongs to the FRAS1 family. | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.937 |