node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bmp15 | Gdf9 | ENSMUSP00000024049 | ENSMUSP00000018382 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | 0.944 |
Bmp15 | H1f8 | ENSMUSP00000024049 | ENSMUSP00000036951 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | Histone H1oo; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. | 0.682 |
Bmp15 | Nlrp5 | ENSMUSP00000024049 | ENSMUSP00000015866 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | NACHT, LRR and PYD domains-containing protein 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. | 0.653 |
Bmp15 | Nobox | ENSMUSP00000024049 | ENSMUSP00000031749 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | Homeobox protein NOBOX; Transcription factor which plays an essential role in postnatal follicle development. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly regulates the transcription of POU5F1 and GDF9 during early folliculogenesis. | 0.856 |
Bmp15 | Npm2 | ENSMUSP00000024049 | ENSMUSP00000057365 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | Nucleoplasmin-2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. | 0.468 |
Bmp15 | Padi6 | ENSMUSP00000024049 | ENSMUSP00000044044 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | Protein-arginine deiminase type-6; Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo. | 0.546 |
Bmp15 | Zar1 | ENSMUSP00000024049 | ENSMUSP00000073221 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition; Belongs to the ZAR1 family. | 0.667 |
Bmp15 | Zp2 | ENSMUSP00000024049 | ENSMUSP00000033207 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. | 0.728 |
Bmp15 | Zp3 | ENSMUSP00000024049 | ENSMUSP00000005073 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation; Belongs to the ZP domain family. ZPC subfamily. | 0.718 |
Gdf9 | Bmp15 | ENSMUSP00000018382 | ENSMUSP00000024049 | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | 0.944 |
Gdf9 | H1f8 | ENSMUSP00000018382 | ENSMUSP00000036951 | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | Histone H1oo; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. | 0.647 |
Gdf9 | Nlrp5 | ENSMUSP00000018382 | ENSMUSP00000015866 | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | NACHT, LRR and PYD domains-containing protein 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. | 0.809 |
Gdf9 | Nobox | ENSMUSP00000018382 | ENSMUSP00000031749 | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | Homeobox protein NOBOX; Transcription factor which plays an essential role in postnatal follicle development. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly regulates the transcription of POU5F1 and GDF9 during early folliculogenesis. | 0.871 |
Gdf9 | Npm2 | ENSMUSP00000018382 | ENSMUSP00000057365 | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | Nucleoplasmin-2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. | 0.542 |
Gdf9 | Ooep | ENSMUSP00000018382 | ENSMUSP00000034900 | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. | 0.455 |
Gdf9 | Padi6 | ENSMUSP00000018382 | ENSMUSP00000044044 | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | Protein-arginine deiminase type-6; Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo. | 0.445 |
Gdf9 | Zar1 | ENSMUSP00000018382 | ENSMUSP00000073221 | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition; Belongs to the ZAR1 family. | 0.815 |
Gdf9 | Zp2 | ENSMUSP00000018382 | ENSMUSP00000033207 | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. | 0.862 |
Gdf9 | Zp3 | ENSMUSP00000018382 | ENSMUSP00000005073 | Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family. | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation; Belongs to the ZP domain family. ZPC subfamily. | 0.808 |
H1f8 | Bmp15 | ENSMUSP00000036951 | ENSMUSP00000024049 | Histone H1oo; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling. | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family. | 0.682 |