node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Btbd35f21 | H2al1m | ENSMUSP00000100634 | ENSMUSP00000073605 | BTB domain-containing 35, family member 21. | Histone H2A; Belongs to the histone H2A family. | 0.692 |
Btbd35f23 | H2al1m | ENSMUSP00000140013 | ENSMUSP00000073605 | BTB domain-containing 35, family member 23. | Histone H2A; Belongs to the histone H2A family. | 0.692 |
H1f7 | H2al1m | ENSMUSP00000127616 | ENSMUSP00000073605 | Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. | Histone H2A; Belongs to the histone H2A family. | 0.703 |
H1f7 | H2al3 | ENSMUSP00000127616 | ENSMUSP00000052025 | Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. | H2A histone family member L3. | 0.593 |
H1f7 | H2ap | ENSMUSP00000127616 | ENSMUSP00000043734 | Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. | Huntingtin-interacting protein M. | 0.607 |
H1f7 | H2bc1 | ENSMUSP00000127616 | ENSMUSP00000056604 | Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. | Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes. Inclusion of the H2AB1-H2BC1/TH2B [...] | 0.497 |
H1f7 | Hils1 | ENSMUSP00000127616 | ENSMUSP00000039866 | Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. | Spermatid-specific linker histone H1-like protein; DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa; Belongs to the histone H1/H5 family. | 0.894 |
H2al1m | Btbd35f21 | ENSMUSP00000073605 | ENSMUSP00000100634 | Histone H2A; Belongs to the histone H2A family. | BTB domain-containing 35, family member 21. | 0.692 |
H2al1m | Btbd35f23 | ENSMUSP00000073605 | ENSMUSP00000140013 | Histone H2A; Belongs to the histone H2A family. | BTB domain-containing 35, family member 23. | 0.692 |
H2al1m | H1f7 | ENSMUSP00000073605 | ENSMUSP00000127616 | Histone H2A; Belongs to the histone H2A family. | Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. | 0.703 |
H2al1m | H2al3 | ENSMUSP00000073605 | ENSMUSP00000052025 | Histone H2A; Belongs to the histone H2A family. | H2A histone family member L3. | 0.754 |
H2al1m | H2ap | ENSMUSP00000073605 | ENSMUSP00000043734 | Histone H2A; Belongs to the histone H2A family. | Huntingtin-interacting protein M. | 0.728 |
H2al1m | H2bc1 | ENSMUSP00000073605 | ENSMUSP00000056604 | Histone H2A; Belongs to the histone H2A family. | Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes. Inclusion of the H2AB1-H2BC1/TH2B [...] | 0.774 |
H2al1m | Hdac2 | ENSMUSP00000073605 | ENSMUSP00000019911 | Histone H2A; Belongs to the histone H2A family. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor co [...] | 0.685 |
H2al1m | Hdac3 | ENSMUSP00000073605 | ENSMUSP00000037981 | Histone H2A; Belongs to the histone H2A family. | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activi [...] | 0.685 |
H2al1m | Hdac8 | ENSMUSP00000073605 | ENSMUSP00000085226 | Histone H2A; Belongs to the histone H2A family. | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (By similarity); Belongs to th [...] | 0.685 |
H2al1m | Hils1 | ENSMUSP00000073605 | ENSMUSP00000039866 | Histone H2A; Belongs to the histone H2A family. | Spermatid-specific linker histone H1-like protein; DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa; Belongs to the histone H1/H5 family. | 0.726 |
H2al3 | H1f7 | ENSMUSP00000052025 | ENSMUSP00000127616 | H2A histone family member L3. | Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. | 0.593 |
H2al3 | H2al1m | ENSMUSP00000052025 | ENSMUSP00000073605 | H2A histone family member L3. | Histone H2A; Belongs to the histone H2A family. | 0.754 |
H2al3 | H2bc1 | ENSMUSP00000052025 | ENSMUSP00000056604 | H2A histone family member L3. | Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes. Inclusion of the H2AB1-H2BC1/TH2B [...] | 0.466 |