node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ak5 | Cpne6 | ENSMUSP00000042785 | ENSMUSP00000073847 | Adenylate kinase isoenzyme 5; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | 0.698 |
Ak5 | Trim46 | ENSMUSP00000042785 | ENSMUSP00000036053 | Adenylate kinase isoenzyme 5; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. | Tripartite motif-containing protein 46; Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon formation, the establishment of neuronal polarity and proper neuronal migration. | 0.527 |
Camkv | Cpne6 | ENSMUSP00000040430 | ENSMUSP00000073847 | CaM kinase-like vesicle-associated protein; Does not appear to have detectable kinase activity. | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | 0.407 |
Camkv | Hpca | ENSMUSP00000040430 | ENSMUSP00000112145 | CaM kinase-like vesicle-associated protein; Does not appear to have detectable kinase activity. | Neuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases; Belongs to the recoverin family. | 0.423 |
Camkv | Olfr1410 | ENSMUSP00000040430 | ENSMUSP00000149621 | CaM kinase-like vesicle-associated protein; Does not appear to have detectable kinase activity. | Olfactory receptor. | 0.453 |
Camkv | Syt1 | ENSMUSP00000040430 | ENSMUSP00000100912 | CaM kinase-like vesicle-associated protein; Does not appear to have detectable kinase activity. | Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neur [...] | 0.521 |
Cpne6 | Ak5 | ENSMUSP00000073847 | ENSMUSP00000042785 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | Adenylate kinase isoenzyme 5; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. | 0.698 |
Cpne6 | Camkv | ENSMUSP00000073847 | ENSMUSP00000040430 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | CaM kinase-like vesicle-associated protein; Does not appear to have detectable kinase activity. | 0.407 |
Cpne6 | Hpca | ENSMUSP00000073847 | ENSMUSP00000112145 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | Neuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases; Belongs to the recoverin family. | 0.434 |
Cpne6 | Mpped1 | ENSMUSP00000073847 | ENSMUSP00000105096 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro). | 0.471 |
Cpne6 | Olfr1055 | ENSMUSP00000073847 | ENSMUSP00000149219 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | Olfactory receptor. | 0.552 |
Cpne6 | Olfr1410 | ENSMUSP00000073847 | ENSMUSP00000149621 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | Olfactory receptor. | 0.456 |
Cpne6 | Os9 | ENSMUSP00000073847 | ENSMUSP00000128914 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity); Belongs to the OS-9 family. | 0.694 |
Cpne6 | Phyhip | ENSMUSP00000073847 | ENSMUSP00000003561 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system. | 0.477 |
Cpne6 | Syt1 | ENSMUSP00000073847 | ENSMUSP00000100912 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neur [...] | 0.441 |
Cpne6 | Trim46 | ENSMUSP00000073847 | ENSMUSP00000036053 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | Tripartite motif-containing protein 46; Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon formation, the establishment of neuronal polarity and proper neuronal migration. | 0.520 |
Hpca | Camkv | ENSMUSP00000112145 | ENSMUSP00000040430 | Neuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases; Belongs to the recoverin family. | CaM kinase-like vesicle-associated protein; Does not appear to have detectable kinase activity. | 0.423 |
Hpca | Cpne6 | ENSMUSP00000112145 | ENSMUSP00000073847 | Neuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases; Belongs to the recoverin family. | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | 0.434 |
Mpped1 | Cpne6 | ENSMUSP00000105096 | ENSMUSP00000073847 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro). | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | 0.471 |
Olfr1055 | Cpne6 | ENSMUSP00000149219 | ENSMUSP00000073847 | Olfactory receptor. | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family. | 0.552 |