node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cyp4a12b | Hsd3b5 | ENSMUSP00000092487 | ENSMUSP00000041442 | Cytochrome P450 4A12B; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids. May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney. Participates [...] | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. | 0.593 |
Cyp4a12b | Mup2 | ENSMUSP00000092487 | ENSMUSP00000074264 | Cytochrome P450 4A12B; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids. May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney. Participates [...] | Major urinary protein 2; Belongs to the calycin superfamily. Lipocalin family. | 0.543 |
Cyp4a12b | Mup3 | ENSMUSP00000092487 | ENSMUSP00000103112 | Cytochrome P450 4A12B; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids. May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney. Participates [...] | Major urinary protein 3; Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females; Belongs to the calycin superfamily. Lipocalin family. | 0.428 |
Gm5938 | Lcn3 | ENSMUSP00000109664 | ENSMUSP00000028304 | Predicted gene 5938; Belongs to the calycin superfamily. Lipocalin family. | Vomeronasal secretory protein 1; Transport of lipophilic molecules, possible pheromone- carrier. | 0.643 |
Gm5938 | Lcn4 | ENSMUSP00000109664 | ENSMUSP00000028283 | Predicted gene 5938; Belongs to the calycin superfamily. Lipocalin family. | Vomeronasal secretory protein 2; Transport of lipophilic molecules, possible pheromone- carrier. | 0.673 |
Gm5938 | Mup17 | ENSMUSP00000109664 | ENSMUSP00000103108 | Predicted gene 5938; Belongs to the calycin superfamily. Lipocalin family. | Major urinary protein 17; Major urinary proteins (Mups) bind pheromones, thus stabilize them and allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (By similarity). | 0.432 |
Gm5938 | Mup2 | ENSMUSP00000109664 | ENSMUSP00000074264 | Predicted gene 5938; Belongs to the calycin superfamily. Lipocalin family. | Major urinary protein 2; Belongs to the calycin superfamily. Lipocalin family. | 0.640 |
Hsd3b5 | Cyp4a12b | ENSMUSP00000041442 | ENSMUSP00000092487 | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. | Cytochrome P450 4A12B; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids. May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney. Participates [...] | 0.593 |
Hsd3b5 | Mup2 | ENSMUSP00000041442 | ENSMUSP00000074264 | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. | Major urinary protein 2; Belongs to the calycin superfamily. Lipocalin family. | 0.537 |
Hsd3b5 | Mup3 | ENSMUSP00000041442 | ENSMUSP00000103112 | NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. | Major urinary protein 3; Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females; Belongs to the calycin superfamily. Lipocalin family. | 0.572 |
Lcn3 | Gm5938 | ENSMUSP00000028304 | ENSMUSP00000109664 | Vomeronasal secretory protein 1; Transport of lipophilic molecules, possible pheromone- carrier. | Predicted gene 5938; Belongs to the calycin superfamily. Lipocalin family. | 0.643 |
Lcn3 | Mup2 | ENSMUSP00000028304 | ENSMUSP00000074264 | Vomeronasal secretory protein 1; Transport of lipophilic molecules, possible pheromone- carrier. | Major urinary protein 2; Belongs to the calycin superfamily. Lipocalin family. | 0.621 |
Lcn4 | Gm5938 | ENSMUSP00000028283 | ENSMUSP00000109664 | Vomeronasal secretory protein 2; Transport of lipophilic molecules, possible pheromone- carrier. | Predicted gene 5938; Belongs to the calycin superfamily. Lipocalin family. | 0.673 |
Lcn4 | Mup2 | ENSMUSP00000028283 | ENSMUSP00000074264 | Vomeronasal secretory protein 2; Transport of lipophilic molecules, possible pheromone- carrier. | Major urinary protein 2; Belongs to the calycin superfamily. Lipocalin family. | 0.622 |
Mup1 | Mup14 | ENSMUSP00000081596 | ENSMUSP00000074696 | Major urinary protein 1; Belongs to the calycin superfamily. Lipocalin family. | Major urinary protein 12; Belongs to the calycin superfamily. Lipocalin family. | 0.819 |
Mup1 | Mup16 | ENSMUSP00000081596 | ENSMUSP00000103107 | Major urinary protein 1; Belongs to the calycin superfamily. Lipocalin family. | Major urinary protein 16. | 0.695 |
Mup1 | Mup17 | ENSMUSP00000081596 | ENSMUSP00000103108 | Major urinary protein 1; Belongs to the calycin superfamily. Lipocalin family. | Major urinary protein 17; Major urinary proteins (Mups) bind pheromones, thus stabilize them and allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (By similarity). | 0.822 |
Mup1 | Mup2 | ENSMUSP00000081596 | ENSMUSP00000074264 | Major urinary protein 1; Belongs to the calycin superfamily. Lipocalin family. | Major urinary protein 2; Belongs to the calycin superfamily. Lipocalin family. | 0.819 |
Mup1 | Mup3 | ENSMUSP00000081596 | ENSMUSP00000103112 | Major urinary protein 1; Belongs to the calycin superfamily. Lipocalin family. | Major urinary protein 3; Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females; Belongs to the calycin superfamily. Lipocalin family. | 0.848 |
Mup14 | Mup1 | ENSMUSP00000074696 | ENSMUSP00000081596 | Major urinary protein 12; Belongs to the calycin superfamily. Lipocalin family. | Major urinary protein 1; Belongs to the calycin superfamily. Lipocalin family. | 0.819 |