node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bud13 | Cwc27 | ENSMUSP00000074490 | ENSMUSP00000022228 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | 0.984 |
Bud13 | Dhx16 | ENSMUSP00000074490 | ENSMUSP00000025292 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | DEAH (Asp-Glu-Ala-His) box polypeptide 16. | 0.987 |
Bud13 | Prpf19 | ENSMUSP00000074490 | ENSMUSP00000136858 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] | 0.987 |
Bud13 | Rbmx2 | ENSMUSP00000074490 | ENSMUSP00000033433 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | 0.999 |
Bud13 | Sf3a2 | ENSMUSP00000074490 | ENSMUSP00000117160 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Splicing factor 3A subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron; Belongs to the SF3A2 family. | 0.986 |
Bud13 | Sf3a3 | ENSMUSP00000074490 | ENSMUSP00000030734 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Splicing factor 3A subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. | 0.983 |
Bud13 | Sf3b2 | ENSMUSP00000074490 | ENSMUSP00000025774 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Splicing factor 3b, subunit 2. | 0.987 |
Bud13 | Sf3b4 | ENSMUSP00000074490 | ENSMUSP00000075709 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Splicing factor 3B subunit 4; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class [...] | 0.983 |
Bud13 | Snip1 | ENSMUSP00000074490 | ENSMUSP00000060721 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | Smad nuclear-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. | 0.995 |
Bud13 | Snrnp200 | ENSMUSP00000074490 | ENSMUSP00000099509 | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. | 0.995 |
Cwc27 | Bud13 | ENSMUSP00000022228 | ENSMUSP00000074490 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family. | 0.984 |
Cwc27 | Dhx16 | ENSMUSP00000022228 | ENSMUSP00000025292 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | DEAH (Asp-Glu-Ala-His) box polypeptide 16. | 0.987 |
Cwc27 | Prpf19 | ENSMUSP00000022228 | ENSMUSP00000136858 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] | 0.984 |
Cwc27 | Rbmx2 | ENSMUSP00000022228 | ENSMUSP00000033433 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | 0.971 |
Cwc27 | Sf3a2 | ENSMUSP00000022228 | ENSMUSP00000117160 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | Splicing factor 3A subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron; Belongs to the SF3A2 family. | 0.964 |
Cwc27 | Sf3a3 | ENSMUSP00000022228 | ENSMUSP00000030734 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | Splicing factor 3A subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. | 0.978 |
Cwc27 | Sf3b2 | ENSMUSP00000022228 | ENSMUSP00000025774 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | Splicing factor 3b, subunit 2. | 0.961 |
Cwc27 | Sf3b4 | ENSMUSP00000022228 | ENSMUSP00000075709 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | Splicing factor 3B subunit 4; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class [...] | 0.967 |
Cwc27 | Snip1 | ENSMUSP00000022228 | ENSMUSP00000060721 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | Smad nuclear-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. | 0.968 |
Cwc27 | Snrnp200 | ENSMUSP00000022228 | ENSMUSP00000099509 | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family. | U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. | 0.998 |