node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Luc7l3 | Prpf40a | ENSMUSP00000021226 | ENSMUSP00000075655 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | 0.900 |
Luc7l3 | Prpf40b | ENSMUSP00000021226 | ENSMUSP00000115869 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | 0.773 |
Luc7l3 | Prpf4b | ENSMUSP00000021226 | ENSMUSP00000077019 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | 0.839 |
Luc7l3 | Rbm25 | ENSMUSP00000021226 | ENSMUSP00000048470 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] | 0.994 |
Luc7l3 | Rbm39 | ENSMUSP00000021226 | ENSMUSP00000105216 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1. May be involved in pre- mRNA splicing process; Belongs to the splicing factor SR family. | 0.955 |
Luc7l3 | Sf1 | ENSMUSP00000021226 | ENSMUSP00000121309 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | Splicing factor 1; Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor (By similarity). Belongs to the BBP/SF1 family. | 0.882 |
Luc7l3 | Srrm1 | ENSMUSP00000021226 | ENSMUSP00000125003 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with lo [...] | 0.709 |
Luc7l3 | Tcerg1 | ENSMUSP00000021226 | ENSMUSP00000158288 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner (By similarity). | 0.624 |
Luc7l3 | Thoc2 | ENSMUSP00000021226 | ENSMUSP00000044677 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cy [...] | 0.527 |
Prpf40a | Luc7l3 | ENSMUSP00000075655 | ENSMUSP00000021226 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | 0.900 |
Prpf40a | Prpf40b | ENSMUSP00000075655 | ENSMUSP00000115869 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | 0.903 |
Prpf40a | Prpf4b | ENSMUSP00000075655 | ENSMUSP00000077019 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. | 0.902 |
Prpf40a | Rbm25 | ENSMUSP00000075655 | ENSMUSP00000048470 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] | 0.976 |
Prpf40a | Rbm39 | ENSMUSP00000075655 | ENSMUSP00000105216 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1. May be involved in pre- mRNA splicing process; Belongs to the splicing factor SR family. | 0.903 |
Prpf40a | Sf1 | ENSMUSP00000075655 | ENSMUSP00000121309 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | Splicing factor 1; Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor (By similarity). Belongs to the BBP/SF1 family. | 0.901 |
Prpf40a | Smu1 | ENSMUSP00000075655 | ENSMUSP00000030117 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | WD40 repeat-containing protein SMU1, N-terminally processed; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). Belongs to the WD repeat SMU1 family. | 0.889 |
Prpf40a | Srrm1 | ENSMUSP00000075655 | ENSMUSP00000125003 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with lo [...] | 0.899 |
Prpf40a | Tcerg1 | ENSMUSP00000075655 | ENSMUSP00000158288 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner (By similarity). | 0.896 |
Prpf40a | Thoc2 | ENSMUSP00000075655 | ENSMUSP00000044677 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cy [...] | 0.912 |
Prpf40b | Luc7l3 | ENSMUSP00000115869 | ENSMUSP00000021226 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing; Belongs to the PRPF40 family. | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family. | 0.773 |